阐明可药物化的 GPCR-ome-猫眼课题宝

阐明可药物化的 GPCR-ome

批准号：

9451604

负责人：

Bryan L. Roth

金额：

$230.13万

依托单位：

UNIV OF NORTH CAROLINA CHAPEL HILL

依托单位国家：

美国

项目类别：

财政年份：

2017

资助国家：

美国

项目状态：

已结题

起止时间：

2017-09-15 至 2023-08-31

来源：

https://reporter.nih.gov/project-details/9451604

关键词：

Animals Area Arrestins Award Biological Process Biology Biomedical Research Cell Line Chemicals Chemistry Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communities Data Set Databases Development Docking Drug Targeting Engineering Epinephrine Funding G-Protein-Coupled Receptors G-substrate Genetic Genetically Engineered Mouse Goals Heart Rate Human Human Genome Individual Informatics Learning Light Lipids Memory Modeling Mus Orphan Pharmaceutical Chemistry Pharmaceutical Preparations Pharmacology Phase Physiological Physiology Plasmids Protein Family Reagent Reporter Reporter Genes Research Research Infrastructure Research Personnel Resource Sharing Resources Respiration Science Signal Pathway Signal Transduction Specific qualifier value Structure Synthesis Chemistry Technology Testing Therapeutic Tissues Transducers Viral Vision Yeasts base cell type chemical genetics chemical synthesis chemokine computer infrastructure computerized tools data resource data sharing experimental study genetic approach human disease in vivo Model medical schools new technology novel novel therapeutics optogenetics programs public health relevance screening targeted treatment tool

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中文摘要

翻译

项目摘要 G蛋白偶联受体(GPCRs)是人类免疫系统中最大的一类药物靶点。人类基因组。在大约390种可下药且无嗅觉的人类GPCR中，存在许多是孤儿和/或研究不足；我们将其称为“全球气候变化报告”。在这里，我们将说明 143个oGPCRs的药理、信号通路、化学生物学、分布和功能列在RFA中。该项目寻求发现和开发特定的、社区可访问的工具- 化学探针分子和转基因动物-使调查人员能够审问 OGPCRs的生物学功能。鉴于GPCRs对所有生物医学领域的核心重要性研究，阐明这些oGPCRs的药理、功能、信号和化学生物学将对治疗学和基础生物医学科学都有深远的影响。

英文摘要

Project Summary G-protein coupled receptors (GPCRs) represent the single largest class of druggable targets in the human genome. Of the 390 or so druggable and non-olfactory human GPCRs there exist many which are orphan and/or understudied; we refer to these as “oGPCRs”. Here we will illuminate the pharmacology, signaling pathways, chemical biology, distribution and function of the 143 oGPCRs listed in the RFA. This project seeks to discover and develop specific, community accessible tools— chemical probe molecules and engineered animals—that enable investigators to interrogate the biological functions of oGPCRs. Given the central importance of GPCRs for all areas of biomedical research, illuminating the pharmacology, function, signaling and chemical biology of these oGPCRs will have far-reaching impact for both therapeutics and basic biomedical science.

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