Center of Biomedical Research Excellence in Cardiovascular Health

 描述(申请人提供)：心血管疾病(CVD)，如心脏病、心力衰竭和中风，仍然是美国男性和女性的头号死因。心血管疾病对特拉华州人的影响远远高于全国平均水平。根据疾病控制中心的数据，特拉华州甚至不在冠心病(CHD)年龄调整死亡率的前一半(即更好的一半)州。更令人不安的是，在50个州中，特拉华州的女性冠心病死亡率排名第39位。高血压患病率同样低于全国平均水平。心血管疾病，如冠心病，在很大程度上是可以预防的，并与该州和地区普遍存在的危险因素有关，如不良饮食、肥胖、缺乏运动和 其他可以变更的行为。美国心脏协会最近将理想的心血管健康定义为没有上述临床表现的心血管疾病，以及血压、胆固醇、血糖、体重、体力活动的最佳水平，以及健康的饮食和不吸烟。在这项申请中，我们寻求建立一个心血管健康生物医学研究卓越中心，旨在通过促进一个子项目新研究人员团队的独立研究职业生涯来促进心血管健康研究，从而获得可持续的资金。该中心将支持五个协作子项目，每个子项目都侧重于心血管健康的血管方面，并旨在过渡到独立资助。分项目将调查个人简历健康下降的机制和后果，以及改善个人简历健康的干预措施。拟议的COBRE还将通过建立核心设施来加强研究基础设施和进行心血管健康研究的能力，这些设施将增强五个分项目主要调查人员和中心其他成员的研究能力。该中心将建立一个心血管研究核心，并支持特拉华州生物技术研究所的生物成像核心。这些核心资源将为心血管功能和健康评估、生物统计学和生物成像提供资源，这些资源将增强子项目调查人员以及中心、大学和地区其他调查人员的心血管研究能力。 最后，我们的目标是发展一个可持续的研究中心，为新的研究人员提供持续的指导和试点资助，并促进有针对性地招聘具有心血管健康专业知识的研究人员。每个子项目调查员都选择了一名科学导师，该导师将继续为完成他们提出的目标提供科学指导。 在职业发展和人际网络方面提供建议。该中心将向其他新的调查人员提供试点资金的机会，以扩大中心的覆盖范围，并为 调查人员从科布雷支持中心毕业后将取代子项目调查人员。该中心将通过招聘两名新的具有心血管健康专业知识的初级教员来进一步扩大规模。搜索范围将是广泛的，以扩大该中心的范围，补充该中心的优势。

 DESCRIPTION (provided by applicant): Cardiovascular diseases (CVD) such as heart disease, heart failure, and stroke remain the number one cause of death in the U.S. for both men and women. CVD affect Delawareans at a rate significantly above the national average. According to the Centers for Disease Control, Delaware is not even in the top half (i.e., better half) of states for coronary heart disease (CHD) age-adjusted death rates. More troubling is that Delaware ranks 39th of 50 states in CHD mortality for women. Hypertension rates are similarly worse than the national averages. CVD such as CHD are largely preventable, and is related to risk factors prevalent in the state and region such as poor diet, obesity, physical inactivity, and other modifiable behaviors. The American Heart Association recently defined ideal cardiovascular health as the absence of clinically manifest CVD as described above, along with optimal levels of blood pressure, cholesterol, blood glucose, body weight, physical activity, as well as a healthy diet and not smoking. In this application, we seek to establish a Center of Biomedical Research Excellence in Cardiovascular Health that aims to catalyze cardiovascular health research by fostering the independent research careers of a team of subproject new investigators, leading to sustainable funding. This center will support five synergistic subproject with each focusing on vascular aspects of cardiovascular health and designed to transition to independent funding. Subprojects will investigate the mechanisms and consequences of declining CV health as well as interventions to improve CV health. The proposed COBRE will also strengthen the research infrastructure and capacity to perform cardiovascular health research by establishing core facilities that will enhance the research capability of the five subproject principal investigators and other members of the Center. This center will establish a Cardiovascular Research Core and support the Delaware Biotechnology Institute Bio-Imaging Core. These core resources will provide resources for assessment of cardiovascular function and health, biostatistics, and bioimaging that will enhance cardiovascular research capabilities of the subproject investigators, as well other investigators in the center, university, and region. Lastly, we aim to develop a sustainable research center that will provide ongoing mentoring and pilot grants to new investigators, and facilitate targeted recruitment of research faculty with expertise in cardiovascular health. Each subproject investigator has chosen a scientific mentor that will continue to provide scientific guidance for completion of their proposed aims in addition to advisement on career advancement and networking. The center will provide the opportunity for pilot funding to other new investigators to increase the reach of the center as well as prepare investigators to replace subproject investigators when they graduate from COBRE support. The center will further expand through the recruitment of two new junior faculty members with expertise in cardiovascular health. The search will be broad in order to expand the center's scope and complement the center's strengths.