The Chernobyl Tissue Bank - Coordinating Center

切尔诺贝利组织库-协调中心 摘要 切尔诺贝利组织库成立于1998年，旨在收集、注释和储存生物样本 在儿童和青少年时期暴露于放射性碘的患者， 切尔诺贝利事故，并随后患上甲状腺癌。该行目前 包含来自4500名患者的材料，所有材料都同意用于研究，包括 基因组学生物样本经过进一步处理，并提供给世界各地的科学家， 研究甲状腺癌发生的分子机制。CTB还 促进为NCI资助的流行病学队列研究收集样本，如乌克兰- 美国队 样本收集是前瞻性的，CTB现在包含一个对照人群，居住在同一个地区， 在缺乏放射性碘的情况下， 暴露，从而促进在年龄匹配的队列中识别辐射生物标志物的研究。 CTB还提供了每个暴露个体的估计甲状腺剂量。 目前的申请是为了在乌克兰继续采集样本，增加进一步的临床试验。 关于治疗和结果的数据以及进一步整理研究数据。成人甲状腺的最新研究 癌症已经表明，在临床注释中添加生物标志物可以提供更好的风险， 对患者进行分层。CTB是最大的收集样本的年轻发病甲状腺 因此是研究生物标志物在癌症风险分层中作用的理想场所， 年轻人甲状腺癌为协助进行这项工作，通讯及科技局现正整理 使用资源中的材料进行的研究。这将使初始计算机模拟研究能够 以确定潜在的风险分层生物标志物，用于进一步研究的验证。的 本申请中寻求的资金是为了支持这种独特的持续和进一步发展， 基础设施演进该基础设施的组成部分有可能用于其他大规模组织库 癌症研究的倡议。

The Chernobyl Tissue Bank -Coordinating Center Abstract The Chernobyl Tissue Bank was established in 1998 to collect, annotate and store biological samples from patients who were exposed in childhood and adolescence to radioiodine in fallout from the Chernobyl accident, and who subsequently have developed thyroid cancer. The bank currently contains material from 4500 patients, and all material is consented for use in research, including genomics. Biological samples are further processed and made available to scientists worldwide for research on the molecular mechanisms underlying development of thyroid cancer. The CTB also facilitates collection of samples for NCI funded epidemiological cohorts studies such as the Ukraine- American cohort. Sample collection is prospective and the CTB now contains a control population, resident in the same geographical areas, who have developed young onset thyroid cancer in the absence of radioiodine exposure, thus facilitating research into identifying biomarkers of radiation in an age- matched cohort. An estimated thyroid dose for each exposed individual is also provided by the CTB. The current application is for continued collection of samples in Ukraine, addition of further clinical data on treatment and outcome and further collation of research data. Recent research in adult thyroid cancer has suggested that addition of biomarkers to clinical annotation provides better risk stratification for patients. The CTB is the largest collection of samples from young onset thyroid cancer and is therefore ideally placed for studies into the role of biomarkers in risk stratification for young onset thyroid cancer. To facilitate this, the CTB is also in the process of collating data from research studies that have used material from the resource. This will enable initial in silico studies to be conducted to identify potential risk stratification biomarkers for validation in further studies. The funds sought in this application are to support the continuation and further development of this unique infrastructure. Elements of the infrastructure have potential for use in other large-scale tissue banking initiatives for cancer research.