UNC/UMN Baby Connectome Project

项目摘要 本申请是对RFA-MH-16-160的响应，标题为 项目(HCP)：婴儿连接体“。北卡罗来纳大学教堂分校的调查人员 希尔大学(UNC)和明尼苏达大学(UMN)将联手实现这些目标 由这位RFA概述。北卡罗来纳大学的团队拥有10多年的招聘和 成像通常是发育中和高危儿童，扫描1000多名从出生到5岁的儿童 1-40岁。生物医学研究成像中心(BRIC)基础设施完善，网址为 UMN的UNC和磁共振研究中心(CMRR)已经到位，以招募和 保留儿科受试者，促进儿科影像研究的协调。我们的过去 正在进行的对未服用镇静剂的儿童(出生-5岁)进行成像的研究 取得了81%的总体成功率和29.3%的流失率。我们的过往记录 证明我们拥有成功实施的关键要素 专注于早期大脑发育的纵向儿科成像研究，这是一个至关重要的 这是RFA的一个方面。我们招募、保留和塑造非镇静剂的能力，通常是在发展中 我们的图像分析团队进一步加强了孩子们的力量，他们开发了新的图像 专门针对早期大脑发育的分析工具。北卡罗来纳大学的专业知识是互补的 并得到UMN团队的专业知识的加强。UMN的CMRR一直是 HCP项目的领导小组，并开发了新的磁共振成像方法 大大缩短了数据采集时间。此外，UMN的团队拥有广泛的 儿童早期发展的行为和认知研究经验。在一起，我们的 联合起来的团队能够很好地完成这个RFA的目标。为此，共有 500名通常在出生到五岁之间发育的儿童将被分两个阶段招募 资料收集地点采用序贯队列，加速纵向研究设计。这个 参与者被分为两个主要组，纵向(n=285)和横向(n=215) 分别为组。这种混合的纵向和横截面设计可实现详细的 应用MRI和MRI从脑结构/功能两方面表征早期脑发育 使用行为评估的行为方面。所有获取的图像和行为 评估将经过广泛的质量保证和控制过程，以确保 获得高质量的数据，并将其传输到华盛顿的中央连接设施 大学。此外，我们还将把我们团队开发的新型图像分析工具集成到 现有的HCP管道。

Project Summary This application is in response to the RFA-MH-16-160, entitled “Lifespan Human Connectome Project (HCP): Baby Connectome”. Investigators at The University of North Carolina at Chapel Hill (UNC) and The University of Minnesota (UMN) will join forces to accomplish the goals outlined by this RFA. The team at UNC has over 10 years of experience in recruiting and imaging typically developing and at-risk children, scanning over 1000 children from birth to five years1-40. Well established infrastructure at the Biomedical Research Imaging Center (BRIC) at UNC and Center for Magnetic Resonance Research (CMRR) at UMN are in place to recruit and retain pediatric subjects and facilitate the coordination of pediatric imaging studies. Our past and ongoing studies for imaging children (birth – five years of age) without sedation have achieved an overall success rate of 81% and attrition rate of 29.3%. Our track record demonstrates that we possess the critical and essential components to successfully conduct longitudinal pediatric imaging studies focusing on early brain development, a critically-important aspect of this RFA. Our ability to recruit, retain, and image non-sedated, typically developing children is further strengthened by our image analysis team, which has developed novel image analysis tools specifically for early brain development. The expertise at UNC is complementary to and strengthened by the expertise of the team at UMN. The CMRR at UMN has been one of the leading groups in the HCP project and has developed novel MR imaging approaches to dramatically shorten data acquisition time. Furthermore, the team at UMN has extensive experience in behavioral and cognitive studies of early child development. Together, our combined team is well positioned to accomplish the goals of this RFA. To this end, a total of 500 typically developing children between birth and five years of age will be recruited across two data collection sites in a sequential cohort, accelerated longitudinal study design. The participants are divided into two main groups, longitudinal (n=285) and cross-sectional (n=215) groups, respectively. This hybrid longitudinal and cross-sectional design enables detailed characterization of early brain development from both brain structural/functional using MRI and behavioral aspects using behavioral assessments. All of the acquired images and behavioral assessments will undergo extensive quality assurance and control processes to ensure that high quality data is obtained and transferred to the Central Connectome Facility at Washington University. In addition, we will integrate novel image analysis tools, developed by our team onto the existing HCP pipelines.