Evaluating New Nicotine Standards for Cigarettes - Administrative Core

项目总结(核心A) 燃烧烟草的使用继续破坏公众健康。美国食品和药物管理局现在有 减少燃烧的烟草产品的尼古丁含量的当局，可能会使香烟和 其他有害产品的成瘾性较小。续签申请提出了三个创新项目，这些项目延长了 我们为了解减少燃烧烟草中尼古丁含量的影响所做的工作 替代尼古丁和烟草产品。管理核心侧重于应对以下挑战 开展拟议的科学研究，使调查小组能够充分利用这一机会 为烟草监管科学领域做出重大贡献。具体地说，这包括以下内容 目标：1)提供基础设施，以促进跨项目和核心以及 实施产生高质量研究的方法、措施和程序。2)促进 向科学家、政策制定者、其他利益攸关方和 整个社区。3)提供和监督NIH支持的博士后和博士后培训计划 对烟草监管研究感兴趣的研究人员。4)通过试点项目产生新的科学 解决与CEEN目标相关的创新研究问题的计划，有助于研究人员 培训，并促进调查人员之间的合作。行政核心将设在大学内 由Eric Donny博士和Dorothy Hatsukami博士(联席董事)领导的匹兹堡大学。四个人中的每一个 职能将由我们团队的一名核心成员监督。一个外部咨询委员会将提供年度投入 关于中心的总体方向、需要解决的领域以及正在取得的进展。单个数据 安全和监测委员会将监督所有三个项目。

PROJECT SUMMARY (CORE A) Use of combusted tobacco continues to devastate public health. The Food and Drug Administration now has the authority to reduce the nicotine content of combusted tobacco products, potentially rendering cigarettes and other harmful products less addictive. This renewal application proposes three innovative projects that extend our work towards understanding the impact of reducing the nicotine content of combusted tobacco in the context of alternative nicotine and tobacco products. The Administrative Core focuses on addressing the challenges of conducting the proposed science and enabling the investigative team to take full advantage of the opportunity to make significant contributions to the field of tobacco regulatory science. Specifically, this includes the following aims: 1) To provide an infrastructure that facilitates integration across the projects and cores and the implementation of methods, measures and procedures that yield high quality research. 2) To facilitate communication and dissemination of information to scientists, policy makers, other stakeholders, and the community at large. 3) To provide and monitor a training plan for NIH-supported pre-doctoral and post-doctoral researchers interested in tobacco regulatory research. 4) To generate new science through a pilot projects program that addresses innovative research questions related to the aims of CENIC, contributes to investigator training, and fosters collaborations among investigators. The Administrative Core will be housed at the University of Pittsburgh under the leadership of Drs. Eric Donny and Dorothy Hatsukami (Co-Directors). Each of the four functions will be overseen by a core member of our team. An External Advisory Board will provide annual input on the overall direction of the Center, areas that need to be addressed, and progress being made. A single Data Safety and Monitoring Board will oversee all three projects.