Frontiers of Aging: From Molecules to Physiology

该申请要求资金支持2019年戈登研究会议（GRC）的生物学 老龄化，将于2019年7月14日至19日在美国缅因州萨丹河的Grand Sumit酒店举行， 戈登研究研讨会（GRS），将于2019年7月13日至14日在同一地点举行， 就在GRC之前。这将是自1962年成立以来的第15次衰老生物学会议。而 老年医学和老年学学会及其会议的重点是医疗、社会和 随着年龄的增长，心理上的后果，在最近的二十年里， 了解衰老过程的潜在机制。虽然衰老的生物学仍然是一个相对较新的 在这个领域，这个GRC已经成为未发表数据展示和讨论的首要论坛， 在这里，人们可以看到令人兴奋的当前科学，也可以看到该领域的未来方向。这 会议的独特之处在于其多样性，这反映在2019年会议的主题：“老龄化前沿：从 分子生理学”。与会科学家将介绍无脊椎动物模式生物的基础研究， 以及对高等生物的研究。适当地，会谈和海报将反映出多样性的 从分子研究到了解衰老如何影响许多细胞和 器官系统和生物体。我们还将听到有关干预措施以调节衰老的令人兴奋的工作。最后 会议将强调成像和单细胞研究的新方法，这将刺激该领域的发展。满足 为了实现这些目标，我们组织了一个多样化的项目，包括以下会议：1）保守的途径，2） 衰老的转化研究，3）染色质和表观遗传学，4）基因组不稳定性，5）代谢物和信号传导， 6)蛋白质稳态，7）营养感测，8）干细胞和克隆动力学，以及9）细胞衰老。的 会议将包括一个小组讨论，指导午餐，和许多网络的机会。我们 多方面的方法，以满足本次会议的目标包括：i）一个计划，丰富的科学多样性， 主题和方法，总主题为“衰老前沿：从分子到生理学”; ii） 促进跨学科合作和促进科学交流的氛围; iii）指导 有机会促进初级调查员与资深调查员之间的互动;以及iv） 支持个人参与的多样性。

This application requests funds to support the 2019 Gordon Research Conference (GRC) on the Biology of Aging, to be held at the Grand Sumit Hotel at Sudnday River (Newry, Maine, USA) on July 14-19, 2019, and the Gordon Research Seminar (GRS), which will be held at the same location on July 13-14, 2019, immediately prior to the GRC. This will be the fifteenth Biology of Aging meeting since its origin in 1962. While geriatrics and gerontology societies and their conferences have focused on the medical, social and psychological consequences of aging, in the most recent two decades there has been a explosion of knowledge on underlying mechanisms of the aging process. While the biology of aging is still a relatively new field, this GRC has become the premier forum for unpublished data presentation and discussions, resulting in a meeting where one can view exciting current science and also see the future directions of the field. This meeting is unique in its diversity, reflected in the theme of the 2019 conference: “Frontiers of Aging: From Molecules to Physiology”. Participating scientists will present basic studies in invertebrate model organisms, as well as studies in higher organisms. Appropriately, the talks and posters will reflect the diversity of the biology of aging by ranging from molecular studies to understanding how aging impacts numerous cellular and organ systems and organisms. We will also hear exciting work on interventions to modulate aging. Finally, this meeting will emphasize novel methods in imaging and single cell efforts, which will stimulate the field. To meet these goals, we have organized a diverse program with the following sessions: 1) conserved pathways, 2) translational studies of aging, 3) chromatin and epigenetics, 4) genomic instability, 5) metabolites and signaling, 6) proteostasis, 7) nutrient sensing, 8) stem cells and clonal dynamics, and 9) cellular senescence. The meeting will incorporate a panel discussion, mentoring lunch, and numerous networking opportunities. Our multifaceted approach to meet the objectives of this meeting include: i) A program rich in scientific diversity of topic and approach with the overarching theme “Frontiers of Aging: From Molecules To Physiology”; ii) An atmosphere to promote interdisciplinary collaborations and stimulate scientific exchange; iii) Mentoring opportunities to promote interactions between junior investigators and senior, established investigators; and iv) Support of individual diversity in participation.