Core B: Training Core

项目摘要/摘要 MDCRC培训核心的总体目标是严格增加 训练有素、有科学能力的研究人员，能够支持生产性的基础科学； 肌营养不良症的翻译和/或临床研究计划。去见这位中央 目的选拔和招收合格的基础科学和临床博士前及 对独立表现出真正兴趣和潜力的博士后候选人 肌营养不良症的基础科学、翻译和/或临床研究。培训核心将 部分支持加州大学洛杉矶分校的一名博士前实习生，并得到加州大学洛杉矶分校研究生的资助 师和CureDuchenne，以及一名来自UF的博士后实习生，由UF提供支持资金 医学院。此外，密歇根大学医学院将提供资金，支持 一名博士后或博士后实习生，在助学金和密歇根大学公共学院期间 健康与健康专业人员将在资助期限内支持博士前实习生。至 有资格获得博士前实习生职位，申请者必须取得超过资格的进步 参加考试，并致力于建立一个论文实验室。UF神经肌肉可塑性T32训练 该计划还将把六个博士前实习生职位中的一个分配给合适的候选人工作 在以肌肉营养不良症为中心的实验室里。此外，Parent Project肌肉营养不良将支持 每年一名临床实习生的部分工作，从任何一个中心地点选择。因此， 总共将支持3或4名博士后、1或2名博士后和1名临床实习生 直接由培训核心、支持机构资金或现有培训计划提供。 除T32计划外，每个职位的实习生都将得到一段时间的支持 到两年。此外，加州大学洛杉矶分校还有一项肌肉细胞生物学的申请正在进行中， 发病机制与治疗T32培训计划。如果获得资金，该计划将为 肌肉营养不良的博士后和博士后实习生。 加州大学和加州大学洛杉矶分校的培训中心将监督和协调一系列正式和 为所有这些受训人员以及博士后、博士后和 在研究人员的实验室中从事肌肉营养不良研究的临床同事 通过千年发展目标中心的项目提供支助。每个实习生将准备一个人 根据他们过去的培训和他们的建议，使用MyIDP制定发展计划 主要导师和论文委员会。取决于实习生的职业阶段 (博士后、博士后或临床研究员)，个性化计划可以由结构化的 教学计划，包括研究方法、专门课程和研讨会，以及 有指导的助学金撰写经验。 培训中心将通过支持1)年度培训来进一步改善培训环境 学员在加州大学和加州大学洛杉矶分校举办研讨会，2)旅行参加一年一度的全国儿童 医院/俄亥俄州立大学/韦尔斯通肌学课程，对于参加课程的人，提供一名实习生 为来自加州大学、加州大学洛杉矶分校和南加州大学的实习生举办演讲之夜，以及，3)前往我们的 韦尔斯通中心在肌肉生物学和疾病方面的新方向国际会议。 此外，重要的是，培训核心将致力于从 每个机构的以肌肉疾病为中心的课程都可以在线提供给社区。

Project Summary/Abstract The overall objective of the MDCRC Training Core is to increase the number of rigorously trained and scientifically competent researchers capable of sustaining productive basic science, translational and/or clinical research programs in muscular dystrophy. To meet this central objective the core will identify and recruit qualified basic science and clinical predoctoral and postdoctoral candidates who demonstrate a genuine interest in, and potential for, independent basic science, translational and/or clinical research in muscular dystrophy. The training core will partially support one predoctoral trainee at UCLA, with supporting funds from UCLA Graduate Division and CureDuchenne, and one postdoctoral trainee at UF, with supporting funds from UF College of Medicine. In addition, the UF College of Medicine will provide funds to support either a predoctoral or postdoctoral trainee for the duration of the grant and the UF College of Public Health & Health Professions will support a predoctoral trainee for the duration of the grant. To be eligible for predoctoral trainee slots, applicants must have progressed beyond their qualifying exam and have committed to a thesis laboratory. The UF Neuromuscular Plasticity T32 Training Program will also allocate one of its six predoctoral trainee slots to a suitable candidate working in a muscular dystrophy-centered lab. Further, Parent Project Muscular Dystrophy will support the partial effort of one clinical trainee per year, to be chosen from any of the center sites. Thus, overall 3 or 4 predoctoral, 1 or 2 postdoctoral and 1 clinical trainee will be supported either directly by the training core, supporting institutional funds, or existing training programs. Trainees in each of these positions, except the T32 program, will be supported for a period of up to 2 years. In addition, UCLA also has an application pending for a Muscle Cell Biology, Pathogenesis and Therapies T32 Training Program. If funded, this program will provide slots for both pre- and postdoctoral trainees in muscular dystrophy. The Training Cores at UF and UCLA will oversee and coordinate a spectrum of formal and informal training activities for all of these trainees, as well as the predoctoral, postdoctoral and clinical fellow researchers engaged in muscular dystrophy research in the labs of researchers supported through the projects of the MDCRC. Each trainee will prepare an Individual Development Plan using MyIDP, based on their past training and recommendations from their primary mentor and thesis committee. Depending on the career stage of the trainee (predoctoral, postdoctoral or clinical fellow), the individualized plan may consist of a structured didactic program involving research methodology, specialized courses and seminars, and mentored grant writing experiences. The Training Cores will further enhance the training environment by supporting 1) annual trainee hosted seminars at UF and UCLA, 2) travel to attend the Annual Nationwide Children’s Hospital/OSU/Wellstone Myology Course and, for those attending the course, a trainee presentation evening for trainees from UF, UCLA and NU and, 3) travel to present at our Wellstone Center aligned New Directions in Muscle Biology and Disease international meeting. In addition, and importantly, the Training Cores will work to make specific course content from muscle disease centered courses from each institution available on-line for the community.