Late Luteal Phase Reactivity to Stress

项目总结/摘要 经前综合征（PMS）是一种精神疾病，影响约20%的育龄妇女， 妇女尽管其发病率很高，但对其病因知之甚少。我们设计了一项未来的研究， 表明在整个月经周期中生殖激素动力学的变化导致PMS，并澄清 这种关系的多域路径。本研究的模型包括急性心理社会应激 反应性成分因此，拟议的研究将澄清月经周期中的时间， 经前综合征诊断妇女和健康对照妇女的应激反应不同。我们假设 经前综合征妇女在黄体晚期急性应激时的皮质醇反应 月经周期这项研究的结果将促进我们对生理和心理的理解。 这种环境使易受影响的妇女在月经前特别容易受到压力的影响。的 该研究计划招募120名月经周期正常的健康女性。他们将图表 她们的症状、月经时间和两个月经周期的排卵情况。这些数据将成为 经前综合征诊断和月经周期阶段的可预测范围。在第三个月经周期，研究 参与者将在月经周期的黄体晚期完成特里尔社会压力测试。的 下丘脑-垂体-肾上腺轴、下丘脑-垂体-性腺轴、心血管系统和情感 将在基线和应激程序后的七个时间点评价状态。获得的知识 将增加我们对研究人群特有的急性应激反应的理解， 以及为我们的长期研究计划收集关键数据，旨在减少临床异质性， 经前综合症。

PROJECT SUMMARY/ABSTRACT Premenstrual Syndrome (PMS) is a psychiatric condition affecting approximately 20% of reproductive-aged women. Despite its high prevalence, very little is known about its etiology. We have designed a future study to show that variation in the reproductive hormone kinetics across the menstrual cycle leads to PMS and to clarify multi-domain pathways of this relationship. The model of this study includes an acute psychosocial stress reactivity component. Therefore, the proposed study will clarify the time within the menstrual cycle at which stress reactivity differs between women with PMS diagnosis and healthy controls. We hypothesize a blunted cortisol response in women with PMS diagnosis upon acute stress challenge during the late luteal phase of the menstrual cycle. Results of this research will advance our understanding of the physiological and psychological milieu which sensitizes susceptible women to be especially vulnerable to stress prior to menstruation. The proposed study will enroll one hundred and twenty healthy women with regular menstrual cycles. They will chart their symptoms, menstruation timing and ovulation for two menstrual cycles. This data will form the basis for PMS diagnosis and predictable bounds of menstrual cycle phases. In the third menstrual cycle, study participants will complete the Trier Social Stress Test session in the late luteal phase of the menstrual cycle. The hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, cardiovascular system and affective state will be evaluated at baseline and at seven time points following the stress procedure. Knowledge gained from this experiment will increase our understanding of acute stress reactivity specific to the study population, as well as collect key data for our long-term program of research, designed to reduce clinical heterogeneity in PMS.