UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain

拟议的UCSF慢性腰痛以患者为中心的机制表型核心中心 (UCSF REACH）将是一个由基础和临床科学家组成的跨学科联盟，致力于了解 阐明慢性下腰痛（cLBP）的生物心理社会机制。UCSF REACH的目标 是定义慢性腰痛（cLBP）表型和疼痛机制，可导致 为所有患者提供有效的个性化治疗。一个根本性的挑战， 改善cLBP患者生活的一个重要原因是，疼痛可能由于以下因素之间的动态相互作用而持续和恶化： 患者的几个特殊因素。然而，主要因素及其相互作用仍然模糊， 他们还没有在一个单一的纵向队列中进行严格的研究。REACH建议克服这一点 通过在研究疾病生物学的研究人员、开发先进的 研究工具和方法，分析大量临床数据档案的科学家， 积极治疗患者。UCSF REACH提出了六个核心：1）行政核心; 2）临床核心; 3）信息学 核心; 4）生物行为核心; 5）病理生理学核心;和6）身体功能和生物力学核心。这些 核心将为一个单一的研究项目提供支持，该项目的重点是开发经过验证的 和可采用的工具，使全面而常规的临床评估和治疗CLBP患者。 REACH还将通过一个丰富计划促进科学交流;课程包括研讨会 以当地和访问科学家为特色，每年与外部咨询委员会举行一次全天务虚会， 一天的专题讨论会，主题是与cLBP的生物心理社会模型相关的旋转。另一个重要的组成部分， REACH是其试点/辅助研究计划。这为利用REACH临床数据提供了种子资金， 丹总的来说，REACH的目标是最佳利用所有可用资源来促进发现， 翻译新的诊断和治疗方法，改善cLBP患者的结果。

The proposed UCSF Core Center for Patient-centric Mechanistic Phenotyping in Chronic Low Back Pain (UCSF REACH) will be an interdisciplinary consortium of basic and clinical scientists dedicated to understanding and clarifying the biopsychosocial mechanisms of chronic low back pain (cLBP). The goal of UCSF REACH is to define chronic low back pain (cLBP) phenotypes and pain mechanisms that can lead to effective, personalized treatments for patients across the population. A fundamental challenge for improving lives of cLBP patients is that pain can perpetuate and worsen as a result of dynamic interaction among several patient-specific factors. However, the principle factors and their interactions remain obscure because they haven't been rigorously investigated in a single longitudinal cohort. REACH proposes to overcome this obstacle by forming a linkage between researchers who study disease biology, experts who develop advanced investigational tools and methods, scientists who analyze vast archives of clinical data, and practitioners who actively treat patients. UCSF REACH proposes six cores: 1) Administrative Core; 2) Clinical Core; 3) Informatics Core; 4) Bio-behavioral Core; 5) Pathophysiology Core; and 6) Physical Function and Biomechanics Core. These cores will provide support to a single research project that is focused on the challenge of developing validated and adoptable tools that enable comprehensive yet routine clinical assessment and treatment of CLBP patients. REACH will also foster scientific exchange through an Enrichment Program; the curriculum includes seminars featuring local and visiting scientists, an annual full-day retreat with the External Advisory Committee, and half- day symposia with a rotating topic relevant to the biopsychosocial model of cLBP. Another vital component of REACH is its Pilot/Ancillary Studies Program. This provides seed money to leverage REACH clinical data and cores. Overall, the object of REACH is to make optimum use of all available resources to catalyze discovery and translation of novel diagnostics and therapeutics that improve outcomes of cLBP patients.