Malaria and long term immunity

疟疾感染了全世界数百万人，造成严重的发病率和死亡率。然而，即使在多年接触疟疾寄生虫后，个人也不会对疟疾产生自然免疫力。已经有多种尝试制造疫苗，产品进入临床试验，但没有一种疫苗能够提供足够的长期保护。我们最近表明，疟原虫已经进化出一种机制，可以杀死长期保护的细胞。这项研究将研究寄生虫杀死这些细胞的机制，以便设计新的治疗方法。

Malaria infects millions of people worldwide causing serious morbidity and mortality. However, individuals do not develop natural immunity to malaria even after years of exposure to the parasite. There have be a multitude of attempts to make a vaccine , with products going to clinical trials, but no vaccine is able to provide adequate protection for the long term. We recently showed that Plasmodium had evolved a mechanism to kill cells that protect in the long-term. This study will investigate the mechanism by which the parasite kill these cells, so that novel therapies can be designed.