Tunable microbubbles for antivascular ultrasound

摘要 抗血管超声是一种利用低振幅超声和微泡治疗癌症的新方法。在 在超声辐射存在下，微泡充当将声能转换成热的微观源 通过振动气泡的粘性阻尼。局部血管内加热损伤内皮细胞， 破坏肿瘤脉管系统。因此，微泡用作能量源和超声波信标以递送 将声能局部地传递到血管内皮。 该研究的目标是对超声增强加热进行数学建模，并使用该模型来指导 使用新的微流体技术合成微泡。该提案有三个具体目标。具体目标 1是使用计算建模来确定产生的机械性能和气泡尺寸分布， 最大的热效应具体目标2将是合成所需尺寸分布和壳的微泡 特性.具体目标3将在流动模型和临床前动物中测试微泡制剂的功效 模型实验结果将与理论计算进行比较。 因此，数学建模和独特的综合方法将提供一个综合的方法， 抗血管治疗拟议的研究开发了一种全新的超声癌症治疗方法， 优于现有技术。我们预计，从拟议的研究中获得的知识将导致 一种治疗癌症的新形式的抗血管疗法。

Abstract Antivascular ultrasound is a novel approach that uses low-amplitude ultrasound and microbubbles to treat cancers. In the presence of ultrasound irradiation, microbubbles act as microscopic sources that convert acoustic energy into heat through viscous damping of oscillating bubbles. The localized intravascular heating damages endothelial cells and disrupt tumor vasculature. Thus microbubbles function as both energy source and ultrasound wave beacons to deliver acoustic energy locally to the vascular endothelium. The goals of the research are to model ultrasound-enhanced heating mathematically and to use the model to guide the synthesis of microbubbles using novel microfluidics techniques. The proposal has three Specific Aims. Specific Aim 1 is to use computational modeling to identify mechanical properties and bubble size distribution that produce maximum thermal effects. Specific Aim 2 will be to synthesize microbubbles of desired size distribution and shell properties. Specific Aim 3 will test the efficacy of microbubble preparations in flow phantoms and preclinical animal model. The experimental results will be compared with theoretical calculations. Thus both mathematical modeling and the unique method of synthesis will provide an integrated approach for antivascular therapy. The proposed research develops a completely new ultrasound cancer treatment with significant advantages over existing techniques. We anticipate that the knowledge gained from the proposed research will lead to a new form of antivascular therapy for treating cancers.