Modulating attention and decision making with closed loop control of low frequency oscillations

项目摘要 同步低频大脑活动，如人类脑电图测量，已牵连在两个正常的 认知和疾病状态如精神分裂症。然而，我们仍然不知道这种变化是否 节律直接改变神经元的信息处理，或者仅仅是副现象。为了解决这个问题，我们 将测量与非人类灵长类动物的任务表现相关的单单位和多单位活动是如何被改变的， 内源性α节律，以及当α节律直接通过 闭环电刺激。该提案将为以下关系提供一种机械解释： α节律，注意力和知觉决策，并验证α直接调制的潜力 节奏作为注意力病理学的治疗方法。

Project Summary Synchronous low-frequency brain activity, as measured by human EEG, has been implicated in both normal cognition and in disease states such schizophrenia. However, we still do not know whether changes in such rhythms directly alter neuronal information processing, or are merely epiphenomenal. To address this issue, we will measure how single and multi unit activity linked to task performance in non-human primates is altered by endogenous alpha rhythms, and how that activity is changed when alpha rhythms are directly modulated via closed-loop electrical stimulation. The proposal will offer a mechanistic explanation for the relationship between alpha rhythms, attention, and perceptual decision making and validate the potential of direct modulation of alpha rhythms as a therapeutic approach to attentional pathologies.