Childhood Diabetes Clinical & Molecular Research Training Program

描述（由申请人提供）：儿童糖尿病临床与分子研究培训项目（CDCMRT）的目标是培养医学博士儿科内分泌学研究员和博士研究员，从事2型糖尿病，胰岛素抵抗，儿童肥胖和健康的学术研究。胰岛素抵抗通常与肥胖有关，并越来越多地导致显性糖尿病，已成为儿童的主要健康问题。该项目的研究人员有机会在国际公认的实验室开始分子和细胞研究的职业生涯，从事胰岛生物学，胰岛素敏感性的生化和分子遗传学研究，或研究不同种族儿童和青少年的人体代谢，能量消耗，肥胖，健康，雄激素过量和代谢综合征的全身病理生理学。目标包括：1)建立一个高质量和富有成效的研究项目；2)在受尊敬的研究期刊上发表文章；3)在奖学金期间申请和获得校外资助；4)至少50%的本项目毕业生在儿童糖尿病、胰岛素抵抗和肥胖研究方面从事学术事业。为了实现这些目标，我们与美国国立卫生研究院资助的威斯康星大学临床和转化研究项目（ICTR）合作开发了一套课程，提供糖尿病和胰岛素抵抗、研究技术、统计和研究设计、医学伦理、科学写作和演讲技巧以及准备拨款申请等方面的培训。CDCMRT的研究机会包括临床、转化和基础科学活动，这些活动都是独立和合作成功的，并直接针对糖尿病和胰岛素抵抗疾病的研究。糖尿病和其他与肥胖相关的代谢紊乱的负担不断增加，我们第一批t32支持的研究人员取得了良好的成就，并且认识到全国缺乏从事儿童肥胖和2型糖尿病培训的基础科学研究人员和儿科内分泌学家，这促使我们为CDCMRT项目寻求持续的资金支持。威斯康星大学医疗保健多样性研究中心将协助CDCMRT招募代表性不足的少数民族实习候选人。如果有机会，CDCMRT项目将继续为受训者提供全面的指导研究培训经验，为他们在儿童糖尿病、胰岛素抵抗和肥胖方面的创新、富有成效的研究事业做好准备。

DESCRIPTION (provided by applicant): The goal of the Childhood Diabetes Clinical & Molecular Research Training Program (CDCMRT) is to train MD pediatric endocrinology fellows and PhD fellows for academic research careers in type 2 diabetes, insulin resistance, obesity and fitness in children. Insulin resistance, usually associated with obesity and increasingly leading to overt diabetes, has become a major health problem in children. Research fellows in this program have the opportunity to begin a career in molecular and cellular research in internationally recognized laboratories engaged in biochemical and molecular genetic studies of pancreatic islet biology, insulin sensitivity, or whole body pathophysiology studying human metabolism, energy expenditure, adiposity, fitness, androgen excess and the metabolic syndrome in ethnically diverse children and adolescents. Objectives include 1) establishment of a high quality and productive research project, 2) development of a progressive record of publication in respected research journals, 3) application for and procurement of extramural grant funding during fellowship, and 4) pursuit of academic careers in childhood diabetes, insulin resistance and obesity research by a minimum of 50% of the graduates of this program. To achieve these objectives, a curriculum has been developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research Program (ICTR) to provide training in diabetes and insulin resistance, research techniques, statistics and study design, medical ethics, scientific writing and presentation skills, and preparation of grant applications. CDCMRT research opportunities involve clinical, translational, and basic science activities that have been both independently and collaboratively successful and are directed towards the study of diabetes and insulin resistance diseases. The continually rising burden of diabetes and other obesity-related metabolic disorders, the strong record of accomplishment of our first group of T32-supported fellows and recognition of a national shortage of basic science researchers and pediatric endocrinologists with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the CDCMRT program. The University of Wisconsin Center for the Study of Diversity in Health Care will assist the CDCMRT in recruiting under-represented minority trainee candidates. Given the opportunity, the CDCMRT program will continue to provide trainees with a comprehensive mentored research training experience that will prepare them for innovative, productive research careers in childhood diabetes, insulin resistance and obesity.