Research Training in Childhood Cancer

摘要 本次Ruth L.Kirschstein国家研究服务奖博士后研究培训补助金续签 申请是响应计划公告PA-16-152提交的，申请提供 机构T32奖项将培训年轻的研究人员，他们将成为独立调查人员 解决人类健康中重要问题的研究。应用程序请求继续提供资源以 每年支持四名拥有医学博士或医学博士学位的医生/科学家，他们接受指导研究 重点介绍儿科恶性肿瘤的病因、发病机制和治疗。这样做的总体目标是 T32计划是为了培训新的研究人员，他们将改善对癌症儿童的护理。其基本原理是 该计划是基于美国儿童癌症的沉重负担和健康- 有记录的迫切需要为年轻医生提供有指导的职业发展支持 使他们成为完全独立和富有成效的实验室研究人员。因此，他们将做好准备 通过运用最先进的专业知识，改善世界各地癌症儿童的健康 关于遗传易感性、环境因素、毒性和相对非特异性等问题 当前治疗方法的性质，以及诱变治疗的长期不良影响。这个节目的设计 涉及利用世界级研究科学家的专业知识，他们担任跨学科的导师 训练。我们已经成功地为基于实验室的和 临床/转化型研究人员。我们相信，这个T32计划自2007年开始以来的进展 证明加州大学旧金山分校拥有培养下一代领导者的远见、经验和基础设施 儿童癌症研究。在这份续签申请中，我们提供证据证明部门或儿科 血液科/肿瘤科与加州大学旧金山分校更广泛的研究社区一起组成了 为年轻医生准备作为独立调查人员从事富有成效的职业的特殊环境 儿童癌症领域。本申请描述了一个全面的认证、培训和培训计划 指导这些人。 此应用程序与人类健康直接相关，因为它请求资金来支持受指导的职业 将成为独立研究人员的优秀年轻医生/研究人员的发展 儿童癌症领域。像这样的项目代表着对公共卫生未来的投资，因为 通过该奖项接受培训的研究人员将有能力利用最先进的研究 解决儿科人群中一个可怕的健康问题的技术。从长远来看， 这一T32奖项提供的强化和创新培训将是治疗儿童的有效新疗法 癌症。

ABSTRACT This Ruth L. Kirschstein National Research Service Award Postdoctoral Research Training Grant renewal application is submitted in response to Program Announcement PA-16-152 for applications to provide institutional T32 awards to train young researchers who will become independent investigators conduting research that addresses important problems in human health. The application requests continued resources to support four physician/scientists each year with MD or MD/PhD degrees who receive mentored research that focuses on the etiology, pathogenesis, and treatment of pediatric malignancies. The overall objective of this T32 program is to train new investigators who will improve the care of children with cancer. The rationale for the program is based on the substantial burden of pediatric cancer in the United States and the well- documented and critical need to provide mentored career development support for young physicians that will enable them to become fully independent and productive laboratory researchers. As such, they will be poised to improve the health of children with cancer throughout the world by bringing state-of-the-art expertise to bear on problems such as inherited predispostions, environmental factors, the toxic and relatively non-specific nature of current therapies, and long-term adverse effects of mutagenic treatments. The design of this program involves harnessing the expertise of world-class research scientists who serve as mentors for interdisiciplinary training. We have successfully implemented distinct trainng tracks for laboratory-based and clincial/translational investigators. We believe that the progress of this T32 program since its inception in 2007 demonstrates tht UCSF has the vision, experience, and infrastructure to train the next generation of leaders in childhood cancer research. In this renewal application, we provide evidence that the Department or Pediatrics and Division of Hematology/Oncology together with the broader UCSF research community comprise an exceptional environment for preparing young physicians for productive careers as independent investigators the field of childhood cancer. This application describe a comprehensive plan for idnetifying, training, and mentoring these individuals. This application is directly relevant to human health as it requests funds to support mentored career development for outstanding young physician/investigators who will become independent researchers in the field of childhood cancer. Programs like this one represent an investment in the future of public health as the researchers who are trained through this award will be equipped to harness state-of-the-art research techniques to attack a formidable health problem in the pediatric population. The long-term outcome of intensive and innovative training provided by this T32 award will be effective new treatments for childhood cancers.