ShEEP Request for Electrospinner Machine

摘要 这项大型设备提案的目的是为同轴电纺装置提供资金 以及所有必要的配件。同轴电纺装置将为生物材料增加一个新的维度 下士迈克尔·J·克雷森兹退伍军人事务医疗中心(CMC-VAMC)的制造能力 费城，特别是神经创伤、神经退行性变和恢复中心的高级研究 (CNNR)和转化性肌肉骨骼研究中心(TMRC)。电纺是一种广泛使用的技术。 用于静电生产纳米纤维，在此过程中使用电力来制造具有 聚合物溶液或熔体的直径从2纳米到几纳米不等。这个过程是一个主要的 由于其多功能性和在纳米尺度上连续生产纤维的能力而备受关注， 这是使用其他标准技术难以实现的。纳米材料在生物医学中的应用 目前处于发展的前沿。与常规材料相比，其比表面积 纳米结构材料本质上要大得多，允许细胞、蛋白质和/或活性物质的粘合 配料。纳米材料在生物医学中有一系列尖端应用，包括但不是 仅限于，组织工程、药物输送、支架和伤口愈合。收购一种新的同轴电机 CMC-VAMC的电气安装和附件将立即产生深远的积极影响 在研究活动上。再加上我们现有的核心设备，这次新的收购将全面装备CMC- VAMC开发基于先进纳米技术的生物材料支架。这将是一个巨大的好处， CMC-VAMC研究企业的整体，对CNNR和TMRC成员特别有用。 购置拟议设备将有助于调查人员克服其目前的限制 由于缺少同轴静电纺丝装置，因此不能在环境中进行纺丝。拟议的设备将允许现有的VA- 资助以退伍军人为中心的研究项目，以更快的步伐推进。新设备还将允许 研究人员将以前所未有的纳米级分辨率开发基于生物材料的先进产品。 总而言之，这将改善专注于退伍军人健康的研究，从而促进VAMC的长期研究 目标。

ABSTRACT The purpose of this large equipment proposal is to provide funding for a Co-Axial Electrospinning setup along with all necessary accessories. The Co-Axial Electrospinning setup would add a new dimension to the biomaterial fabrication capacity at Corporal Michael J. Crescenz Veterans Affairs Medical Center (CMC-VAMC) in Philadelphia and specifically advance research at the Center for Neurotrauma, Neurodegeneration & Restoration (CNNR) and Translational Musculoskeletal Research Center (TMRC). Electrospinning is a widely used technique for the electrostatic production of nanofibers, during which electric power is used to make polymer fibers with diameters ranging from 2 nm to several nanometres from polymer solutions or melts. This process is a major focus of attention because of its versatility and ability to continuously produce fibers on a scale of nanometres, which is difficult to achieve using other standard technologies. The application of nanomaterials in biomedicine is currently at the forefront of development. Compared with conventional materials, the surface area of nanostructured material is inherently much larger, allowing for the adhesion of cells, proteins and/or active ingredients. There are a range of cutting-edge applications of Nanomaterials in Biomedicine, including, but not limited to, Tissue Engineering, Drug Delivery, Scaffolds, and Wound Healing. Acquisition of a new Co-Axial Electropsinning setup and accessories for the CMC-VAMC will have an immediate and profound positive impact on research activities. Coupled to our existing core equipment, this new acquisition will fully equip the CMC- VAMC to develop advanced nanotechnology based biomaterial scaffolds. This will be a great benefit to the entirety of the CMC-VAMC research enterprise, and particularly useful for members of the CNNR and TMRC. Acquisition of the proposed equipment will help the investigators overcome limitations in their current environment due to the lack of a co-axial electrospinning setup. The proposed equipment will allow current VA- funded Veteran-centric research projects to move forward at a much faster pace. The new device will also allow investigators to develop advanced biomaterial based products with unprecedented nano-scale resolution. Together, this will improve research focused on Veterans health, thus furthering the VAMC’s long-term research goals.