Omics core

组学摘要 这是集成链中心OMICS核心的延续。的复杂性和交织 蛋白质组学、代谢组学和生物信息学有力地表明，最有益和合理的步骤是 本轮申请是将这三个实体归类到一个保护伞下，允许更紧密和更多 有效利用技术，以利于中心调查人员进行的研究。每个组件 由Ciborowski博士领导的蛋白质组学，由Siuzdak博士领导的代谢组学和生物信息学 现在由古达博士领导)带来了广泛的各自专业知识，在过去的密切合作中得到了支持 五年的连锁融资。为Chain Center及其调查人员提供先进的分析和 生物信息技术平台将按照以下具体目标完成：1.提供 通过质谱学和生物信息学平台实现蛋白质组学和代谢组学的分析技术 进行全面的数据分析；2.提供实验设计、数据分析和软件方面的专业知识 支持与该中心有关的研究人员所需研究的工具；3.开发新的方法 蛋白质组学和代谢组学研究的分析技术，以满足当前和未来的需求 链调查员；4.使基因组规模的技术和最先进的生物信息学工具能够 该中心的需要；以及5.协调该中心在神经艾滋病和中心内各级的工作 社区。这些具体目标旨在满足中心的目标，三名核心调查人员 不仅带来了蛋白质组学、代谢组学和生物信息学方面的重要专业知识，而且还拥有良好的 对HIV及其神经生物学等慢性疾病的了解，以及在 神经艾滋病研究，这有助于连锁中心调查人员的成功可能性。其中之一 预计蛋白质组学实验的结果将与代谢组学数据相结合，并通过 在这一核心中使用生物信息学分析工具是一项合作努力，将导致综合数据收集， 同时具备共享和分析功能，不仅使我们的 调查人员达到了他们的科学目标，但产生了一个独特的艾滋病毒感染资源的中心 神经系统和衰老。进一步整合这一核心，将使其领导人认识到 该中心的研究人员将从其他组学支持中受益。此外，所有信息都将共享 通过行政核心以面对面(小型研讨会)或在线(网络研讨会)的形式提供的机制 会议以及多种教育途径，即与数据库、专题和 教科书。Siuzdak、Ciborowski和Guda博士在吸引新研究人员方面有着坚实的记录。

Omics Abstract This is a continuation of an integrated CHAIN Center OMICS core. The complexity and intertwining of proteomics, metabolomics and bioinformatics strongly indicated that the most beneficial and logical step for this round of application is to group these three entities under one umbrella allowing for closer and more effective use of technology to the advantage of research conducted by center’s investigators. Each component of this ‘Omics Core (Proteomics led by Dr. Ciborowski, Metabolomics led by Dr. Siuzdak and Bioinformatics now led by Dr. Guda) brings extensive respective expertise supported by close collaboration during the past five years of CHAIN funding. Support of CHAIN Center and its investigators with advanced analytical and bioinformatics technology platforms will be accomplished according to the following specific aims: 1. To provide analytical technologies in proteomics and metabolomics via mass spectrometry and bioinformatics platforms for comprehensive data analyses; 2. To provide expertise in experimental design, data analyses and software tools in support of studies needed by investigators associated with this center; 3. To develop new approaches and analytical techniques for proteomic and metabolomics studies to meet the current and future needs of CHAIN investigators; 4. To enable genome-scale technology and state-of-the-art bioinformatic tools for the needs of the Center; and 5. To coordinate efforts of this core at all levels within the neuroAIDS and Center’s communities. These specific aims are designed to meet the Center’s goals, and the three Core investigators not only bring significant expertise in proteomics, metabolomics and bioinformatics but also have a good understanding of chronically developing condition such as HIV and its neurobiology, and experience in neuroAIDS studies, which facilitate the likelihood of success of CHAIN Center investigators. One of expectations is that results of proteomics experiments will be integrated with metabolomics data, and through the use of bioinformatics analysis tools in this Core a collaborative effort will result in integrated data collection, sharing and analysis capabilities that are simultaneously divers and integrated, not only enabling our investigators to meet their scientific aims but generating a unique resource for HIV infection of the central nervous system and ageing. Further integration of this core, will enable its leaders to recognize which researchers of this center would benefit from the other omics support. Moreover, all information will be shared via mechanisms provided by the administrative core in form of in-person (mini symposia) or on-line (webinars) meetings as well as multiple educational avenues, i.e. tutorials associated with databases, monographic and textbooks. Drs. Siuzdak, Ciborowski and Guda have solid track record of attracting new investigators.