MACS/WIHS Combined Cohort Study: Cook County Clinical Research Site (CC_CRS)

项目摘要/摘要 尽管有了更有效的抗逆转录病毒疗法，但优化艾滋病毒健康的斗争- 受感染的男性和女性仍在继续，他们死于过早的医学共病，包括 心血管疾病、肺部疾病、神经认知功能障碍和恶性肿瘤。芝加哥厨师的目标 MACS/WIHS联合队列研究的县临床研究站点(CRS)，前身为芝加哥 妇女机构间艾滋病毒研究，旨在促进对艾滋病毒相关共病和发病机制的了解 通过科学创新和转化方法，让基础、临床、 行为和社区健康科学。与其他国家临床研究网站和 数据分析和协调中心，该网站制定了一个统一的科学议程，旨在 全面描述艾滋病毒感染者过早发病和死亡的机制。煮 县CRS调查人员将领导或联合领导行为科学、恶性肿瘤、神经认知、 睡眠科学和发病机制，包括与肝病、口腔健康、微生物组科学相关的倡议 和结果裁决。库克县CRS将通过以下方式为艾滋病毒和多学科科学做出贡献 通过开放、好奇心强的方式促进协作，分享想法以及丰富的数据和样本 由合格专家组成的队列资源，他们可以进一步促进对艾滋病毒的机械性理解- 相关的共病。库克县CRS还将支持有前途的和多样化的早期职业 研究人员和艾滋病毒研究的新手通过试点资助、意向指导和与 支持独立筹资的资源。最后，通过队列参与者的广泛参与和 社区合作伙伴，库克县CRS将迅速传播关键研究结果，并获得对 对于受艾滋病毒影响的芝加哥人来说，最紧迫的问题是告知未来的科学方向。

Project Summary/Abstract Despite the availability of ever more potent antiretroviral therapy, the struggle to optimize the health of HIV- infected men and women continues, as they suffer and die from premature medical co-morbidities including cardiovascular, pulmonary disease, neurocognitive dysfunction and malignancies. The goal of the Chicago Cook County Clinical Research Site (CRS) of the MACS/WIHS Combined Cohort Study, formerly the Chicago Women's Interagency HIV Study, is to advance understanding of HIV-related co-morbidities and pathogenesis through scientific innovation and a translational approach involving investigators from basic, clinical, behavioral and community health sciences. In collaboration with the other national Clinical Research Sites and the Data Analysis and Coordinating Center, the site has developed a Unified Science Agenda that aims to holistically describe mechanisms underlying premature morbidity and mortality in HIV-infected persons. Cook County CRS investigators will lead or co-lead projects in Behavioral Science, Malignancy, Neurocognition, Sleep Science and Pathogenesis including initiatives related to Liver Disease, Oral Health, Microbiome Science and Outcome Adjudication. The Cook County CRS will contribute to HIV and multidisciplinary science by fostering collaboration through an open, inquisitive approach, sharing ideas and the rich data and specimen resources of the cohort with qualified experts who can further advance mechanistic understanding of HIV- associated co-morbidities. The Cook County CRS will also support promising and diverse early career investigators and those new to HIV research through pilot grants, intentional mentorship, and linkage to resources to support independent funding. Finally, through expansive engagement of cohort participants and community partners, the Cook County CRS will rapidly disseminate key study findings and obtain insight into the most pressing issues for Chicagoans affected by HIV to inform future scientific direction.