Animal Core Facility

加强对胰腺癌检测和治疗的基础研究和翻译研究 癌症，并且为了加强NDSU的生物医学研究，我们建议建立一个具有研究的Cobre 重点开发胰腺癌早期诊断和治疗的新策略。建议数 国立国立大学胰腺癌诊断和治疗策略中心最初将由以下人员组成 四个主题相关的项目，每个项目都由一名初级调查员指导。可通过以下方式获得的资源 该中心，特别是动物核心中心，将允许初级调查人员利用最先进的方法 KPC转基因小鼠异种原位移植治疗药物的疗效和毒性研究 胰腺癌模型。四个项目，连同拟议的行政领导，动物 核心设施、试点项目和新招聘的教员将推动这个高度整合的团队朝着我们的目标前进 建立一个专注于胰腺癌研究的可持续中心。拟议的动物核心设施将 促进协调获得高标准的动物服务，包括动物护理和实验。 动物核心的长期目标是加强我们机构的生物医学研究 基础设施。这一目标将通过建立一流的核心设施来实现，该设施提供畜牧业 和动物模型的住房以及对相关生物医学研究的研究支持 问题。Core的主要重点将放在胰腺癌研究上。然而，一旦建立起来， 动物核心将为解决广泛的生物医学问题提供一个出色的平台。这个 动物核心有以下具体目标。 1)建立动物核心设施，通过扩大，促进胰腺癌研究的卓越，以及 加强NDSU现有的动物设施。我们将通过招聘必要人员来实现这一目标 (经理和技术人员)和采购最先进的设备和研究仪器。 2)为初级个人调查员的科学和动物需求提供服务，试点项目 研究人员、新的和现有的教职员工、博士后研究员和研究生- 年科布雷项目。核心中心的服务将包括动物护理和实验、培训、礼仪 发展，并执行IACUC的规定。 3)搭建长期可持续的动物核心研究平台。动物核心设施将使NDSU 和合作的科学家(包括即将毕业的科布雷研究人员和其他人)以加强研究 计划，并因此更具竞争力。动物核心将促进和维持生产力， 在生物医学研究领域获得外在支持的职业。

To enhance basic and translational studies devoted to the detection and treatment of pancreatic cancer, and to strengthen biomedical research at NDSU, we propose to establish a COBRE with a research focus on developing new strategies for the early diagnosis and treatment of pancreatic cancer. The proposed Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at NDSU will be initially comprised of four thematically interrelated projects, each directed by a Junior Investigator. The resources available through the Center, in particular the Animal Core, will allow the Junior Investigators to utilize state-of-the-art methods to study the efficacy and toxicity of new therapeutic agents using mouse orthotopic xenograft and KPC transgenic models of pancreatic cancer. The four projects, together with the proposed Administrative Leadership, Animal Core Facility, Pilot Projects, and new faculty recruits, will propel this highly integrated group towards our goal to develop a sustainable center focused on pancreatic cancer research. The proposed Animal Core Facility will facilitate coordinated access to high standard animal service including animal care and experiments. The long-term goal of the Animal Core is to strengthen our institution's biomedical research infrastructure. This goal will be accomplished by establishing a premiere core facility that provides husbandry and housing for animal models as well as research support for the investigation of relevant biomedical questions. The primary focus of the Core will be on pancreatic cancer research. However, once established, the Animal Core will provide an outstanding platform for addressing a wide range of biomedical questions. The Animal Core has the following Specific Aims. 1) Establish the Animal Core Facility to foster excellence in pancreatic cancer research by expanding, and enhancing the existing NDSU animal facility. We will achieve this aim by recruiting essential personnel (manager and technician) and procuring state of the art equipment and research instrumentation. 2) Provide services for the scientific and animal needs of the individual Junior Investigators, Pilot Project Investigators, New and Existing Faculty, Postdoctoral Fellows, and graduate students associated with the five- year COBRE project. The services from the Core will include animal care and experiments, training, protocol development, and enforcing IACUC regulation. 3) Build a long-term sustainable Animal Core Research Platform. The Animal Core Facility will enable NDSU and collaborating scientists (including graduating COBRE investigators and others) to strengthen research programs and, as a result, be more competitive. The Animal Core will promote and sustain productive, extramurally-supported careers in biomedical research.