Conduct of feasibility and in life studies to evaluate systemic exposure to crumb rubber via multiple routes

该项目的目标是通过不同的暴露情景(灌胃、饮用水、饲料、吸入和皮肤)评估短期使用橡胶屑后的可行性和系统性暴露。美国现有11,000多个人造草坪田，每年新增约1,200个。最令人担忧的草皮成分是橡胶碎屑，由回收的汽车轮胎制成。橡胶屑含有许多潜在的致癌和有毒物质，但人们对在已安装的场地上工作的人接触这些危险成分的了解还不够清楚。从NTP毒理学研究中获得的信息将为公共卫生机构提供信息，为暴露和健康评估提供信息。由于橡胶碎屑材料的物理性质，毒理学研究的进行面临着巨大的挑战。除了告知未来进行NTP毒性研究的可行性，并通过各种途径提供全身暴露的信息外，这些数据还将帮助其他研究人员设计毒性研究并解释结果数据。 关键词：毒性、橡胶屑、全身暴露、人造草坪。

The goal of this project is to evaluate feasibility and systemic exposure following short-term administration of crumb rubber by various exposure scenarios (gavage, drinking water, feed, inhalation and dermal). Over 11,000 synthetic turf fields exist in the U.S., with approximately 1,200 being added annually. The component of turf that is of most concern is crumb rubber infill, made from recycled automotive tires. Crumb rubber contains numerous potential carcinogenic and toxic substances, yet the exposure of people playing on installed fields to these hazardous components is not well understood. Information gained from NTP toxicology studies will provide public health agencies with information to inform exposure and health assessments. There are significant challenges to the conduct of toxicology studies due to the physical nature of the crumb rubber material. In addition to informing feasibility of conduct of future NTP toxicity studies and provide information on systemic exposure by various routes, these data will aid other researchers design toxicity studies and interpret the resulting data. Keywords: toxicity, crumb rubber, systemic exposure, artificial turf.