Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) Consortium

 描述（由申请人提供）：本合作协议（U 01）申请响应NIH RFA-DA-15-015，青少年大脑认知发育（ABCD）研究。夏威夷大学（UH）是成熟研究前瞻性研究（PRISM）联盟的9个研究站点中的第2个。该联盟的目标是建立一个全国性的、多地点的纵向队列，以前瞻性地研究从青春期早期到SU和SU障碍风险期的物质使用（SU）对神经发育和行为的影响。这项对11，000名儿童进行的为期10年的纵向研究将测量大脑发育，SU，认知，情感，执行功能，心理健康，身体健康，环境，并收集生物标本用于未来的遗传和表观遗传研究。该联盟有一个优化的研究方案和4个具体目标：1）使用先进的多模态神经影像学来评估发病前的因素和与SU的不同模式对发育中的大脑结构和功能的影响。2)解开SU对身体健康，心理社会和认知发展，学业成绩，动机和情绪调节的不同模式的预测因子和后果。3)检查使用的物质的数量和组合如何影响精神病理学的表达，反过来，精神病理学的出现如何影响SU。4)评估所使用的每种物质如何促进其他物质的使用（网关相互作用）。为了进一步评估这些年轻人的神经化学和神经生理学变化，我们将与宾夕法尼亚大学、加州大学洛杉矶分校、犹他州、夏威夷、JHU和贝勒大学的PRISM研究中心合作，对大约一半的志愿者进行1H MR波谱（MRS）、灌注MRI（使用动脉自旋标记或ASL）和定量磁化率绘图（QSM）。我们正在为我们的网站提出一个多PI领导方法。PI具有互补性和跨学科的专业知识，涵盖了管理这个综合项目所需的所有领域。我们在SUD研究、临床评估、受试者抽样和招募以及MR方法学方面拥有专业知识。我们网站的其他独特资格是：1）我们可以接触到种族多样化的人口（包括夏威夷原住民和太平洋岛民）受到SUD的影响不成比例，2）我们在SUD和高危人群（如青少年）中的MR研究方面有着良好的记录，以及3）我们参与并领导了几项涉及复杂的多模态MR结局测量和受试者评估的多中心研究。因此，我们拥有所有必要的资源、经验和专业知识来进行拟议的研究，我们的努力将补充其他优秀研究中心的努力，共同实现PRISM联盟的总体目标。

 DESCRIPTION (provided by applicant): This cooperative agreement (U01) application responds to NIH RFA-DA-15-015, Adolescent Brain Cognitive Development (ABCD) study. The University of Hawaii (UH) is #2 of 9 Research Sites of the Prospective Research in Studies of Maturation (PRISM) Consortium. The Consortium's objective is to establish a national, multisite, longitudinal cohort to prospectively examine the neurodevelopmental and behavioral effects of substance use (SU) from early adolescence through the period of risk for SU and SU disorders. This 10-year longitudinal study of 11,000 children will measure brain development, SU, cognition, emotion, executive function, mental health, physical health, environment, and collect biospecimens for future genetic and epigenetic studies. The Consortium has an optimized research protocol and 4 specific aims: 1) Using advanced multi-modal neuroimaging to evaluate premorbid factors and the impact associated with diverse patterns of SU on structure and function of the developing brain. 2) Disentangle the predictors and consequences of diverse patterns of SU on physical health, psychosocial and cognitive development, academic achievement, motivation and emotional regulation. 3) Examine how the quantity and combination of substances used affect the expression of psychopathology and, conversely, how the emergence of psychopathology influences SU. 4) Assess how each substance used contributes to the use of other substances (gateway interactions). To further evaluate neurochemical and neurophysiological changes in these youth, we will additionally perform 1H MR spectroscopy (MRS), perfusion MRI (using arterial spin labeling or ASL), and quantitative susceptibility mapping (QSM), in approximately half of our volunteers, in collaboration with PRISM sites at Penn, UCLA, Utah, Hawaii, JHU, and Baylor. We are proposing a multi-PI leadership approach for our site. The PIs have complementary and inter- disciplinary expertise that encompasses all areas required to manage this comprehensive project. We have expertise in SUD research, clinical assessments, subject sampling and recruitment, and MR methodology. Additional unique qualifications of our site are: 1) we have access to a racially diverse population (including Native Hawaiians and Pacific Islanders) that is disproportionately affected by SUD, 2) we have a strong track record of MR research in SUD and at risk populations, such as adolescents, and 3) we have participated in and led several multi-center research studies that involve complex multi-modal MR outcome measures and subject assessments. Therefore, we have all the necessary resources, experience and expertise to conduct the proposed research, and our effort will complement that of other outstanding research sites to collectively achieve the overall goals of the PRISM Consortium.