Clinical Core

西奈山ADRC(SANO)：临床核心(核心B)-研究摘要 临床核心提供认知障碍患者的临床和生物学特征方面的专业知识 丧失和痴呆症以及识别非受损老年人的能力。这些专业知识被用来招募 并保持不同年龄、临床表现、教育程度、种族和 种族。这一特征良好的队列支持一系列广泛的痴呆症和认知研究 在ISMMS、西奈山卫生系统(MSHS)和国家倡议内进行，例如 国家阿尔茨海默病协调中心(NACC)，全基因组阿尔茨海默氏症研究(GWAS)，阿尔茨海默氏症 疾病合作研究(ADCS)和阿尔茨海默病神经成像倡议(ADNI)。的作用 核心是开发和实施临床程序，并收集高标准的生物标志物 老年人的特征跨越正常、前驱症状和受影响对象的不同阶段 变成“做好研究准备”的群体。临床核心提供研究对象、组织和数据，以及 与疾病的临床表现、病程、治疗反应、 和招聘可行性，以帮助指导中心内和广泛范围内研究的设计和实施 在MSHS内部。在该中心内，临床核心提供研究的基本要素：受试者和 他们参与生物标志物和遗传学核心的临床特征； 脑捐赠和其他标本传播到神经病理学核心；临床和教育 与矿石和REC核心的项目和受训人员互动的专业知识。核心创新于 开发评估工具；将评估应用于新的人群；适应新的成像 将技术转化为临床“现实世界”；以及对新的、研究不足的或重新调整用途的化合物进行临床试验。 核心有丰富和成功的历史，接触在痴呆症研究和研究中代表性不足的群体 此应用程序中内置了继续执行此操作的条款。该中心积极培训年轻的调查人员和 支持希望研究临床人群认知的其他领域的研究人员。

Mount Sinai ADRC (Sano): Clinical Core (Core B) – Research Summary The Clinical Core provides expertise in the clinical and biological characterization of individuals with cognitive loss and dementia and the ability to identify non-impaired older individuals. This expertise is utilized to recruit and maintain a cohort of participants of varying ages, clinical presentations, educational attainment, races and ethnicities. This well-characterized cohort supports a broad array of dementia and cognitive research conducted within the ISMMS, the Mount Sinai Health System (MSHS,) and national initiatives such as the National Alzheimer's Coordinating Center (NACC), the Genome Wide Alzheimer's Study (GWAS), Alzheimer's Disease Cooperative Studies (ADCS), and the Alzheimer's Disease Neuroimaging Initiative (ADNI). The role of the core is to develop and implement clinical procedures and collect biomarkers for the high standard characterization of elders spanning the spectrum of normal, prodromal, and various stages of affected subjects into “research-ready” cohorts. The Clinical Core provides subjects, tissue, and data for studies as well as clinical research expertise related to clinical manifestations of disease, disease course, treatment responses, and recruitment feasibility to help guide the design and implementation of studies within the Center and broadly within the MSHS. Within the Center, the Clinical Core provides the essentials for research: the subjects and their clinical characterization to participate in the Biomarker and Genetics Cores; the clinical characterization of brain donations and other specimens disseminated to the Neuropathology Core; clinical and educational expertise to interact with the projects and trainees of the ORE and REC cores. The Core innovates in the development of assessment tools; application of assessments to new populations; adaptation of new imaging technologies into the clinical `real world'; and clinical trials of novel, under-studied or repurposed compounds. The Core has a rich and successful history of outreach to groups underrepresented in dementia research and provisions to continue this are built into this application. The Core is active in training young investigators and supporting investigators from other fields who wish to study cognition in their clinical populations.