Laboratory Animal Shared Resource

实验动物共享资源(LASR)的使命是促进对动物的人文关怀和利用 支持在罗斯威尔公园进行的基础研究和转化研究的实验室动物。设施和 两个兽医项目都得到了AAALAC国际认证，表明了对人道的承诺 负责任的动物研究和对良好科学的奉献。LasR旨在提供最高的 动物护理标准，由一名专家技术人员执行日常健康观察的所有方面， 兽医护理、设施和设备维护以及外科和技术服务。LASR 为CCSG成员提供全方位的实验动物护理和使用服务，包括屏障设施 具有全自动环境控制，用于研究动物模型的住房。LASR提供 兽医保健、动物健康监测、诊断实验室设施、辐射服务、 支持200多家动物保护和利用研究所的研究、技术服务和师资培训 委员会批准的动物使用协议和专业畜牧业，有训练有素的工作人员执行 在生物安全柜内更换笼子以维护病原体期间的所有饲养操作- 动物被关在微型隔离(MI)笼子系统中的自由环境。主场地是一栋四层楼高的建筑，约5万层 净平方英尺(NSF)隔间，于1998年开业，位于医学研究综合体大楼内。一个 邻近的癌症细胞中心大楼中还提供了9000个NSF。动物存货量波动很大 在该设施中饲养了3.9万至4.2万只动物。在本报告所述期间(2013-2017)，法律援助服务机构担任 罗斯韦尔共有129名用户，其中106名(82%)是CCSG成员。LasR支持科学家进行 活体研究。为了进一步推动癌症中心内研究项目的成功，LASR正在积极 参与改进通常成为实现目标的新方法或创新的程序 拟进行的动物研究。LASR的具体目标是：1)为罗斯威尔公园CCSG成员 获得最先进的设施、专门的畜牧和兽医服务，以提供住房和护理 他们的实验室动物用于研究；2)推动从基础和体外翻译的过渡 利用体内肿瘤动物模型研究临床应用与实践；3)提供智力 和技术支持，在实验期间协助所有CCSG项目的基础和临床研究人员 项目和手稿的设计、执行和/或赠款的撰写。LASR的目标是支持 癌症中心的生物医学研究，同时保持最高标准的人文关怀和使用 实验室里的动物。LasR将继续保持AAALAC国际保证认证 动物护理的黄金标准。

The mission of the Laboratory Animal Shared Resource (LASR) is to promote the humane care and use of laboratory animals in support of basic and translational research conducted at Roswell Park. The facilities and veterinary program are both accredited by AAALAC International demonstrating the commitment to humane and responsible animal research and dedication to good science. LASR is designed to offer the highest standards of animal care, with an expert technical staff performing all aspects of daily health observations, veterinary medical care, facility and equipment maintenance and surgical and technical services. The LASR offers CCSG members a full spectrum of laboratory animal care and use services including barrier facilities with fully automated environmental controls for the housing of research animal models. The LASR provides veterinary medical care, animal health surveillance, diagnostic laboratory facilities, irradiation services, research technical services and faculty training in support of more than 200 Institute Animal Care and Use Committee-approved animal use protocols and specialized animal husbandry with trained staff that performs all husbandry manipulations during cage changing inside Bio-Safety cabinets for maintenance of a pathogen- free environment of animals held in micro isolation (MI) caging systems. The main site is a four-story ~50,000 net square feet (nsf) vivarium, which opened in 1998, located in the Medical Research Complex building. An additional 9,000 nsf is available in the adjacent Cancer Cell Center building. The animal inventory fluctuates between 39,000 to 42,000 animals housed in the facility. In the reporting period (2013-2017), the LASR served a total of 129 Roswell users, of which 106 (82%) were CCSG members. LASR supports scientists that conduct in vivo studies. To further the success of the research programs within the cancer center, the LASR is actively involved in refinement of procedures that usually become new methods or innovations to accomplish the goals of proposed animal studies. The Specific Aims of the LASR are: 1) To provide Roswell Park CCSG members access to state-of-the-art facilities, specialized husbandry and veterinary services for the housing and care of their laboratory animals used in research; 2) To propel the transition from basic and translational in vitro research into clinical application and practice using in vivo animal models of cancer; 3) To provide intellectual and technical support to assist basic and clinical investigators in all CCSG programs during experimental design, execution of projects and manuscript and/or grant writing. The goal of the LASR is to support biomedical research at the cancer center while maintaining the highest standards for the humane care and use of the laboratory animals. LASR will continue to maintain the AAALAC International accreditation for assurance of gold standards of animal care.