University of Michigan Training Program in ELSI Research

摘要 遗传学和基因组学研究正在迅速产生科学发现，技术进步， 临床应用，每一个都对医学和公共卫生有重要意义。为了实现 然而，要实现“基因组学革命”，许多伦理、法律的和社会影响（ELSI）将 需要积极应对。自1990年以来，国家人类基因组研究所（NHGRI） 资助了一个ELSI研究项目，重点关注基因组学研究中的伦理困境， 基因检测在医疗环境中的整合，以及法律的、监管和公共政策方面的挑战。的 ELSI计划最近被纳入更广泛的NIH机构培训赠款计划（T32），这表明 认识到需要培养下一代ELSI研究人员，以应对日益增长的挑战， 基因组学研究的进步带来的机遇。 密歇根大学（UM）ELSI研究培训计划将通过提供以下服务来满足这一需求： 为博士前和博士后学者提供综合的跨学科指导。我们建议支持两个 每年有两名博士后研究员。每个研究员将参加一个个性化的，为期2年的 培训课程，将在以下领域提供指导、知识和技能：1） 基因组科学和医学; 2）生物伦理学的核心原则和框架; 3）定量和定性 研究方法; 4）赠款写作和手稿准备;和5）跨学科的实施 ELSI研究项目。该培训计划将设在公共卫生的UM学校，在密切 与UM医学院的单位合作，包括生物伦理学与社会科学中心， 医学，人类遗传学系。该培训计划将由18名教师组成的团队 在ELSI研究和/或临床遗传学方面具有丰富经验的导师，以及NIH的良好记录- 资助项目和研究指导;这些导师拥有相关学科的专业知识，包括 生物伦理学、临床心理学、遗传咨询、遗传健康/风险沟通、健康教育、健康 法律，卫生服务研究，医疗决策，医学遗传学，医学社会学，肿瘤学， 儿科学、公共政策、科学/技术研究和统计遗传学。拟议的培训计划 我还将利用密歇根大学的大量资源，包括职业发展 密歇根大学临床与健康研究所的研究方法培训机会， 社会研究所和拉克姆研究生院的机构支持。

ABSTRACT Genetics and genomics research are rapidly generating scientific discoveries, technological advances, and clinical applications, each with important implications for medicine and public health. In order for the promise of the “genomics revolution” to be achieved, however, numerous ethical, legal and social implications (ELSI) will need to be proactively addressed. Since 1990, the National Human Genome Research Institute (NHGRI) has funded an ELSI Research Program focused on areas including ethical dilemmas in genomics research, integration of genetic testing in healthcare settings, and legal, regulatory and public policy challenges. The ELSI Program's recent inclusion in the broader NIH Institutional Training Grants Program (T32) signals a recognition of the need to train the next generation of ELSI researchers to face the growing challenges and opportunities posed by advances in genomics research. The University of Michigan (UM) Training Program in ELSI Research will help meet this need by providing integrated, interdisciplinary instruction for predoctoral and postdoctoral scholars. We propose to support two predoctoral and two postdoctoral fellows per year. Each fellow will participate in an individualized, 2-year course of training that will provide mentoring, knowledge and skills in areas including 1) the current state of genomic science and medicine; 2) core principles and frameworks in bioethics; 3) quantitative and qualitative research methods; 4) grant writing and manuscript preparation; and 5) the implementation of interdisciplinary ELSI research projects. The training program will be based in the UM School of Public Health, in close collaboration with units in the UM Medical School including the Center for Bioethics & Social Sciences in Medicine, and the Department of Human Genetics. The training program will feature a team of 18 faculty mentors with vast experience in ELSI research and/or clinical genetics and a proven track record of NIH- funded projects and research mentoring; these mentors possess expertise across relevant disciplines including bioethics, clinical psychology, genetic counseling, genetic health / risk communication, health education, health law, health services research, medical decision-making, medical genetics, medical sociology, oncology, pediatrics, public policy, science / technology studies, and statistical genetics. The proposed training program will also draw upon the considerable resources of the University of Michigan, including the career development programs of the Michigan Institute for Clinical & Health Research, research methods training opportunities at the Institute for Social Research, and institutional support from the Rackham Graduate School.