Training of the Pediatric Physician-Scientist

项目摘要/摘要 这是儿科医生-科学家T32的第二次续签申请 华盛顿大学医学院的培训计划。儿科医生-科学家的游戏 在增进知识以改善儿童健康方面发挥关键作用。以满足持续的国家需求 为了补充临床博士后研究金级别的儿科医生-科学家队伍， 我们的计划支持每年4名奖学金获得者的导师职业发展途径，最多支持2名 几年来，通过利用华盛顿大学医学院内丰富的生物医学资源 医学，我们的儿童健康研究中心和医学中心校园。就像我们为 在过去的15年里，我们计划的长期目标是培养专注于 应用基础和基础研究领域的最新进展开展儿科疾病导向生物学的研究 翻译科学，如发育生物学、细胞生物学、免疫学、遗传学/基因组学、 和系统生物学。该提案的具体目标包括：1)受保护的指导研究 经验丰富的调查人员涵盖了广泛的学科在 华盛顿大学医学院和儿科，必修课 实验室管理、科学严谨性、统计学、资助力、 负责任地进行研究和生物医学信息学3)个性化的具体课程 根据学员的调查范围，4)不断向学员、导师和 方案领导，以及5)发展妇女和任职人数不足的受训人员 少数族裔。该项目现在已有15年的历史，其记录非常好，超过了全国 基准(15年T-K转换率=52%；本周期=57%)，并将最终结束 基础/转化型科学家与儿科临床医生之间的知识差距。加里·A·西尔弗曼， 项目主任由医学博士担任，培训由医学博士David Hunstad担任 导演。学员将继续使用我们由机构资助的最先进的核心设施， 提供例如全基因组/外显子DNA测序、生物信息学、冷冻-EM成像、 基因组编辑和模型动物开发，以促进儿科疾病状态的研究。这个 该计划的长期目标正在实现，因为它的学员有助于我们了解 人类未来几十年的发育性疾病，同时进化成下一代 未来几代儿科医生的科学领袖、榜样和导师- 科学家。

PROJECT SUMMARY / ABSTRACT This is the second renewal application for support of the Pediatric physician-scientist T32 training program at the Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the Pediatric physician-scientist pipeline at the clinical post-postdoctoral fellowship level, our program supports a mentored career development pathway for 4 Scholars per year for up to 2 years by leveraging a wealth of biomedical resources within the Washington University School of Medicine, our Child Health Research Center and the Medical Center campus. As we have done for the past 15 years, the long-term objective of our program is to develop Trainees that focus their research efforts on Pediatric disease-oriented biology by applying recent advances in the basic and translational sciences; such as developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators encompassing a wide range of disciplines within the Washington University School of Medicine and the Department of Pediatrics, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible conduct of research, and biomedical informatics 3) individualized specific coursework based on the Trainees’ areas of investigation, 4) continuous feedback to the Trainees, mentors and program leadership, and 5) the development of Trainees who are women and underrepresented minorities. The program, now fifteen years old, has an excellent track record by exceeding national benchmarks (15-year T to K conversion rate = 52%; this cycle = 57%), and will ultimately close the knowledge gap between basic/translational scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D. serves as the Program Director, and David Hunstad, M.D. serves as the Training Director. The Trainees will continue to utilize our institutionally-funded state-of-art core facilities that provide, for example, whole genome/exome DNA sequencing, bioinformatics, cryo-EM imaging, genome editing and model animal development, to facilitate the study of Pediatric disease states. The long-term goals of this program are being realized as its Trainees contribute to our understanding of human developmental diseases for decades to come, while evolving into the next generation of scientific leaders, role models and mentors for subsequent generations of Pediatric physician- scientists.