Clinical Science Research Core (CSRC)

项目摘要/摘要-临床科学研究核心： 临床科学研究核心(CSRC)加强和促进与营养/肥胖相关的临床和 通过手术协助研究人员对人体进行研究的翻译研究 由两个子核组成。临床研究绩效分核心通过以下方面协助促进临床研究：i) 受试者招募，二)临床研究的规划和执行(即，各种示踪剂和非 示踪剂方案，如高胰岛素-正常血糖钳夹程序，多示踪剂餐试验， 静脉和口服葡萄糖耐量试验，以及动静脉平衡研究，以评估底物和 胰岛素动力学)，iii)身体成分评估[通过使用双能X射线吸收法(DEXA)， 豆荚、豆荚、磁共振成像(MRI)和磁共振波谱(MRS)]，四) 静脉示踪剂和激素溶液的混合，v)组织(脂肪、肌肉、肠道)的活检 样本，vi)运动(耐力和力量)和体能测试，vii)间接量热法，) 生活方式(饮食控制、行为治疗、运动训练和体重减轻/体重增加)干预，九) 胃口行为(味觉和偏好)测试，以及x)心血管评估(例如， 超声心动图、内皮功能、颈动脉内膜-中层厚度)。新陈代谢动力学分会- CORE提供全面的服务和培训，以研究代谢功能的不同领域，包括：i) 设计示踪剂和非示踪剂方案以评估体内底物动力学(例如葡萄糖和脂肪酸通量， 极低密度脂蛋白-甘油三酯分泌率)、胰岛素敏感性、胰岛素分泌率和细胞功能，ii)样本 血液、组织和组织中代谢底物的稳定同位素浓缩的处理和测量 原代人体组织培养样本，以及iii)示踪剂和非示踪剂数据的数学建模 代谢动力学、胰岛素敏感性、胰岛素分泌率和细胞功能的评估。此外， 中国证监会为研究人员、工作人员和研究员提供这些临床研究领域的培训， 既有一对一的实践教学，也有研讨会和系列讲座。 将这些服务组合在一个核心中提供了一个凝聚力的组织结构，从而促进 开展复杂的临床研究，促进NORC之间的跨学科合作 研究人员，并降低了基础科学家、非内科医生和年轻研究人员的门槛 希望进行临床研究。中国证监会还确保支持的所有研究和程序 按照联邦和地方(州和医院)的法规进行 涉及人类受试者的研究。

PROJECT SUMMARY/ABSTRACT- Clinical Science Research Core: The Clinical Science Research Core (CSRC) enhances and facilitates nutrition/obesity-related clinical and translational research by assisting investigators in conducting studies in human subjects through the operation of two sub-cores. The Clinical Studies Performance sub-core facilitates clinical research by assistance with: i) subject recruitment, ii) planning and performance of clinical studies (i.e., a diverse array of tracer and non- tracer protocols such as the hyperinsulinemic-euglycemic clamp procedure, multi-tracer meal tests, intravenous and oral glucose tolerance tests, and arterial venous balance studies, to assess substrate and insulin kinetics), iii) body composition assessments [by using dual energy X-ray absorptiometry (DEXA), BodPod, Peapod, magnetic resonance imaging (MRI), and magnetic resonance spectroscopy (MRS)], iv) mixing of intravenous tracer and hormone solutions, v) acquisition of tissue (adipose, muscle, intestine) biopsy samples, vi) exercise (endurance and strength) and physical performance testing, vii) indirect calorimetry, viii) lifestyle (diet manipulation, behavioral therapy, exercise training, and weight loss/weight gain) interventions, ix) ingestive behavior (taste perception and preference) testing, and x) cardiovascular assessments (e.g., echocardiography, endothelial function, carotid artery intima-media thickness). The Metabolic Kinetics sub- core provides comprehensive services and training to study diverse areas of metabolic function, including: i) design of tracer and non-tracer protocols to evaluate in vivo substrate kinetics (e.g. glucose and fatty acid flux, VLDL-triglyceride secretion rate), insulin sensitivity, insulin secretion rates, and -cell function, ii) sample processing and measurement of stable isotope enrichment of metabolic substrates in blood, tissue, and primary human tissue culture samples, and iii) mathematical modeling of tracer and non-tracer data for the assessment of metabolic kinetics, insulin sensitivity, insulin secretion rates, and -cell function. In addition, the CSRC provides training for investigators, their staff, and research fellows in these areas of clinical research, both in the form of one-on-one hands-on instruction as well as through seminars and lecture series. Combining these services within one Core provides a cohesive organizational structure that facilitates the performance of complex clinical research studies, fosters interdisciplinary collaborations between NORC investigators, and reduces the barriers for basic scientists, and non-physician and young investigators who wish to conduct clinical research. The CSRC also ensures that all studies and procedures that are supported by the core are conducted in compliance with federal and local (state and hospital) regulations regarding research involving human subjects.