Wake Forest NeuroNext Clinical Site (WAKENN)

维克森林浸信会健康中心(WFBH)致力于在我们的6家医院医疗系统和26个县的集水区为我们历史上代表性较低和地理位置不同的患者提供神经学临床试验。加入NeuroNEXT网络作为临床站点将把目前未覆盖的东南大西洋纳入国家网络，并通过我们多样化的患者组合来增强它。我们四分之三的患者生活在农村社区，相当大一部分人低于联邦贫困水平。值得注意的是，北卡罗来纳州密西西比河以东拥有最多的美洲印第安人，也是全国增长最快的拉美裔人口之一。此外，WFBH是美国少数几个完全集成的学术健康系统之一。我们带来了临床试验方面的经验、敬业的领导能力以及培训下一代临床医生-科学家神经学方面的成功记录。在新任首席执行官/院长的大力支持下，WFBH拥有强大的研究基础设施，包括CTSA资助的临床和翻译科学研究所(CTSI)、玛雅·安杰卢健康公平中心、NIA资助的Pepper老年美国人独立和阿尔茨海默氏症核心中心，以及出色的公共卫生科学部，他们在多地点临床试验方面拥有丰富的经验，并与NIH协调中心合作。WFBH还致力于培养多样化的下一代神经科学研究人员。WFBH在过去5年中获得了12项神经科学K奖，并且Neuroology在临床试验收入方面处于机构领先地位(WFBH获得的非NIH收入的17.5%)。凭借这些优势，我们将通过实现这些具体目标，为NeuroNEXT网络做出有意义的贡献：目标1：利用我们地理、种族和经济上的多元化集水区，有效地招募和留住来自历史上服务不足的人群的临床试验参与者。这包括北卡罗来纳州西部和弗吉尼亚州南部，阿巴拉契亚农村地区，以及大量的城市、西班牙裔和非裔美国人。目标2：让我们的患者社区参与研究过程，利用我们目前的利益相关者外联基础设施来促进NeuroNEXT试验。目标3：利用我们综合学术医学中心的资源来激励、协调和透明地跟踪临床试验的创建、增长和实施。目的4：招募和培训下一代神经学研究人员，以设计和实施有意义的和可重复的临床试验。我们经验丰富的合作PI、Brasher博士和Duncan博士，以及WFBH的整个研究领导团队，热忱地为NeuroNEXT网络提供我们独特的患者组合、强大的研究团队、强大的神经病学临床试验研究环境、高效的监管和合同执行团队，以及对神经疾病有前景的疗法进行高效和可重复试验的专业知识。

Wake Forest Baptist Health (WFBH) is committed to providing neurology clinical trials to our historically underrepresented and geographically diverse patients across our 6-hospital health system and our 26-county catchment area. Joining the NeuroNEXT network as a clinical site would bring the currently uncovered Southeast Atlantic into the national network and enhance it with our diverse patient mix. Three-quarters of our patients live in rural communities and a substantial proportion are below the federal poverty level. Of note, North Carolina has the largest population of American Indians east of the Mississippi River, and one of the fastest-growing Hispanic populations in the nation. Furthermore, WFBH is one of the few fully integrated academic health systems in the U.S. We bring experience in clinical trials, dedicated leadership, and a successful track record of training the next generation of clinician-scientists in neurology. With a strong commitment of institutional resources from our new CEO/Dean, WFBH has robust research infrastructure that includes our CTSA-funded Clinical and Translational Science Institute (CTSI), Maya Angelou Center for Health Equity, NIA-funded Pepper Older Americans Independence and Alzheimer’s Disease Core Centers, and an outstanding Division of Public Health Sciences with extensive experience with multi-site clinical trials and working with NIH coordinating centers. WFBH is also dedicated to training a diverse next generation of neuroscience investigators. WFBH has received 12 Neuroscience K awards in the last 5 years and Neurology is an institutional leader in clinical trial revenues (17.5% of non-NIH income received by WFBH). With these multiple strengths, we will contribute meaningfully to the NeuroNEXT network by carrying out these Specific Aims: AIM 1: To leverage our geographically, ethnically, and economically diverse catchment area to effectively enroll and retain clinical trial participants from historically underserved populations. This includes western North Carolina and southern Virginia, rural Appalachia, and large urban, Hispanic, and African American populations. AIM 2: To engage our patient community in the research process, leveraging our current stakeholder outreach infrastructure to promote NeuroNEXT trials. AIM 3: To leverage the resources of our integrated academic medical center to incentivize, coordinate, and transparently track clinical trial creation, growth, and implementation. AIM 4: To recruit and train the next generation of neurology researchers to design and implement meaningful and reproducible clinical trials. Our experienced co-PIs, Drs. Brashear and Duncan, together with the entire WFBH research leadership, are enthusiastic in offering to the NeuroNEXT network our unique patient mix, strong investigative group, robust research environment for neurology clinical trials, efficient regulatory and contract execution teams, and expertise in conducting efficient and reproducible trials of promising therapies for neurologic disorders.