Comparative electrophysiology: Visual event-related potentials and oscillations

人类视觉事件相关电位（ERPs）和脑电图（EEG）测量各种 不同的认知操作。视觉ERPs和EEG是诊断和治疗糖尿病的重要工具。 研究神经和精神病理学障碍，除了揭示健康的大脑如何转变， 视觉输入转化为适当的反应。然而，我们无法确切地确定哪些大脑区域 产生特定的ERP成分和EEG振荡，与部署视觉注意力、视觉工作 存储器存储和监视任务性能。该项目的更新将支持我们的本地化工作， 视觉任务中ERP成分和振荡信号的来源 使用人类和非人类灵长类动物。在后者中，我们将记录非侵入性ERP和EEG 同时颅内记录局部场电位。这些录音将用于执行 从大脑内部对神经发生器进行正向建模猴子的初步证据， 人类执行相同的视觉任务证明了人类和猕猴ERP之间的同源性 分量和EEG中特定频带的调制提供了 视觉注意、视觉信息在视觉工作记忆中的储存和表现监测。通过 同时研究人类和猴子，该项目将允许临床医生和健康研究人员使用 视觉和反应诱发的EEG活动和ERP组件记录非侵入性从人类， 了解特定的大脑区域是否正常运作，并开发特定的动物模型。 紊乱

Human visual event-related potentials (ERPs) and the electroencephalogram (EEG) measure a variety of different cognitive operations during visual processing. Visual ERPs and EEG are vital tools in diagnosing and studying neurological and psychopathological disorders, in addition to revealing how the health brain turns visual inputs into appropriate responses. However, it is not possible to definitively determine what brain areas generate specific ERP components and EEG oscillations related to deploying visual attention, visual working memory storage, and monitoring task performance. The renewal of this project will support our work localizing the sources of ERP components and oscillatory signatures elicited during the performance of visual tasks using both humans and nonhuman primates. In the latter we will record noninvasive ERPs and EEG simultaneously with intracranial recordings of local field potentials. These recordings will be used to perform forward modeling of the neural generators from inside the head. Preliminary evidence from monkeys and humans performing identical visual tasks demonstrates homology between human and macaque ERP components and the modulation of specific frequency bands in the EEG providing indices of the deployment of visual attention, the storage of visual information in visual working memory, and performance monitoring. By concurrently studying humans and monkeys this project will allow clinicians and health researchers to use the visually and response evoked EEG activity and ERP components recorded noninvasively from humans to access whether specific brain regions are functioning properly and also to develop animal models of specific disorders.