Project 1: Kamphaeng Phet Family Cohort Study

项目摘要 这项题为“家庭感染力量与登革热疾病负担”的研究建议 泰国“涉及到美国和泰国的研究，以了解成员如何在 所有年龄段的家庭对接触登革热病毒都有反应，如果他们的临床结果是 被感染了。这是一项对500个家庭和大约3000名家庭成员进行的独特研究 在泰国北部总共用了10年的时间来了解人们对感染的反应 随着时间的推移和不同类型的登革热病毒的变化。这项研究将使我们能够理解 一个家庭中来自多个年龄段的免疫反应；了解人们是如何受到保护的 以及确定登革热如何在人群中传播的因素。 这个项目是一个独特的机会，跟踪家庭在10年的密集接触 登革热高度流行地区的登革热传播。项目活动侧重于定义 登革热感染的家庭负担，了解群体免疫在传播中的作用 动态，并确定保护的相关性和疾病严重程度的相关性。这些 活动源于我们了解登革热发病机制和 确定感染和传播的风险因素。这个项目和它的目标是高度 与计划项目的总体目标相关，这些目标是将方法推进到 预防和治疗登革热相关感染和疾病。

Project Abstract This research proposal, entitled “Familial force of infection and dengue disease burden in Thailand” involves studies in the United States and Thailand to understand how members within a family of all ages respond to exposure to dengue virus and what their clinical outcome is if infected. This is a unique study following 500 families and approximately 3,000 family members in Northern Thailand over a total of 10 years to understand how people’s response to infection changes over time and to different types of dengue virus. This study will allow us to understand the immune response from multiple ages in one family; understand how people are protected from infection or not; and determine the factors on how dengue is spread in the population. This project is a unique opportunity to follow families across 10 years of intense exposure to dengue transmission in an area hyperendemic for dengue. Project activities focus on defining the familial burden of dengue infection, understanding the role of herd immunity in transmission dynamics, and identifying correlates of protection and correlates of disease severity. These activities are derived from our central objectives of understanding dengue pathogenesis and identifying risk factors for infection and transmission. This project and its objectives are highly relevant to the overall objectives of the Program Project which are to advance methods to prevent and treat dengue-related infection and illness.