Chemistry & DMPK Core

项目总结/摘要 自然产品神经科学卓越研究中心（CORE-NPN） 密西西比药学院（UM），十年前通过COBRE赠款发起，已经开发了一种 致力于评估天然产品对中枢神经系统的影响的多学科团队 （CNS）。该中心现在有潜力发展和维持一个创新的和独立资助的 该研究中心专注于治疗与神经系统相关的疾病。药物化学 代谢和药代动力学（DMPK）是药物发现迭代周期的重要组成部分， 嵌入在点击到铅和铅优化阶段。COBRE的化学/DMPK研究核心 CORE-NPN计划代表了一个共享的核心设施，其目标是为生物医学研究者/用户提供服务 在合成药物化学和DMPK方面提供广泛的咨询、专业服务和培训， 在NPN计划中定义。该核心的定位是成为合成，分析和早期- 天然产物和合成小分子药物发现与开发阶段DMPK评价 通过实现以下具体目标开展活动：（1）加强化学/DMPK研究 核心通过为用户提供增强的服务，访问和培训，在国家的最先进的仪器， （2）促进发展服务的基础设施， 促进COBRE CORE-NPN研究;（3）：通过以下方式加快核心可持续性的长期计划 扩大用户基础，研究伙伴关系和协作，整合收费服务结构， 机构支持，并通过监测用户的需求来适应变化。这些目标将有助于 将化学DMPK核心转变为一个完全自我维持的设施，提供专门的研究 提供必要的服务和培训机会，以支持研究者和弥合药物发现差距， 为用户提供药物化学/DMPK方面的咨询、培训和服务，帮助缓解 与化合物获取和评估相关的瓶颈。

PROJECT SUMMARY/ABSTRACT The Center of Research Excellence in Natural Products Neuroscience (CORE-NPN) at The University of Mississippi School of Pharmacy (UM), initiated ten years ago through a COBRE grant, has developed a multidisciplinary team committed to evaluating the effects of natural products on the central nervous system (CNS). The Center now has the potential to develop and sustain an innovative and independently funded research center focused on treating disorders associated with the nervous system. Medicinal chemistry, drug metabolism, and pharmacokinetics (DMPK) are vital components of the iterative cycle of drug discovery, both embedded in hit-to-lead and lead optimization stages. The Chemistry/DMPK Research Core of the COBRE CORE-NPN program represents a shared core facility with the goal of serving biomedical investigators/users with consultation and specialized services and training in synthetic medicinal chemistry and DMPK as broadly defined within the NPN program. This Core is positioned to become a leader in synthesis, analysis, and early- stage DMPK evaluation of natural product and synthetic small-molecule drug discovery and development campaigns by accomplishing the following Specific Aims: (1) To strengthen the Chemistry/DMPK Research Core by providing users with enhanced services, access, and training in state-of-the-art instrumentation, specialized techniques, and scientific expertise; (2): To advance an infrastructure of developmental services to facilitate COBRE CORE-NPN research; (3): To accelerate a long-term plan for sustainability of the Core through expansion of the user base, research partnerships and collaborations, integration of a fee-for-service structure, institutional support, and adaptation to changes by monitoring the needs of the users. These aims will facilitate the transition of the Chemistry-DMPK Core into a fully self-sustained facility providing specialized research services and training opportunities essential in supporting investigators and bridging the drug discovery gap by providing users with consultation, training, and services in medicinal chemistry/DMPK, helping to alleviate the bottleneck associated with compound acquisition and evaluation.