USC/UCLA Center on Biodemography and Population Health

概述摘要 南加州大学/加州大学洛杉矶分校生物人口学和人口健康中心（CBPH）代表了一个独特的，高度 南加州大学戴维斯老年学学院 (USC)以及格芬医学院的老年医学和老年学多校区项目 在加州大学洛杉矶分校（UCLA），每一个都专注于研究， 关于衰老的教学CBPH长期以来一直是促进基于理论的 将生物测量纳入以人口为基础的研究， 生物测量协议，以及对生物机制的理论研究， 社会、经济、心理、医疗和环境因素“渗透到皮肤下”， 健康随着年龄的变化。CBPH开发了独特的临床和实验室基础设施， 开展试点项目，以更好地理解和使用生物人口指标， 人口研究，支持在大量国家和地区收集更可靠和有效的数据， 国际调查，并在计量和验证方面取得进展，使人口调查 跟上衰老科学的发展步伐。此应用程序提出了一组活动 旨在（一）扩大和加强生物人口学领域的理论发展，使我们专注于 新一代的生物标志物，反映了反映基本机制的分子和细胞过程 （二）继续努力吸引新的和有前途的研究人员到该领域，（三）加强我们的 中心在支持开发、验证、实施和传播新的 更好的生物统计测量协议。CBPH的具体目标是：（1）支持和 促进生物人口学研究，以了解影响人口健康的多种相互作用的因素 (with一个特别注重扩大和深化我们的理解的生物途径，通过 生命过程中的哪些经历和暴露会影响健康轨迹，以及这些影响如何 可能因亚组和环境而异）;（2）进一步发展活跃的生物人口研究社区 通过在一个学者网络中招募成熟和有前途的初级研究人员， 生物人口研究;（3）为试点项目提供资金，以支持尖端的生物人口研究; (4)支持开发和传播新的研究技术，方法和数据，通过我们的 研究资源和传播核心和行政核心的传播活动。这种进步 需要支持人口健康模型的发展，这些模型提供了急需的证据， 政策规划者关于最有效的干预点，以改善人口健康， 健康差距。CBPH已经开发了基础设施，资源和专业知识，以实现其 目标，并继续在推进生物人口老龄化研究的重要领导作用。 OMB编号0925-0001/0002（2012年8月批准至2015年8月31日修订版）页码续页格式页码

Overview Abstract The USC/UCLA Center on Biodemography and Population Health (CBPH) represents a unique and highly successful collaboration between the Davis School of Gerontology of the University of Southern California (USC) and the Multi-campus Program in Geriatric Medicine and Gerontology in the Geffen School of Medicine at the University of California at Los Angeles (UCLA), each of which focuses exclusively on research and teaching on aging. The CBPH has a longstanding role as a leader in efforts to promote theory-based integration of biological measurement into population-based studies, on-going development and validation of biological measurement protocols, and theoretically motivated research on the biological mechanisms by which social, economic, psychological, medical and environmental factors “get under the skin” to influence the process of health change with age. The CBPH has developed unique clinical and laboratory infrastructure and pilot projects to improve understanding and use of biodemographic indicators, increase indicators available to population studies, support more reliable and valid collection of data across a large number of national and international surveys, and made advances in measurement and validation that allow population surveys to keep pace with scientific advances in the science of aging. This application proposes a set of activities designed to (i) expand and enhance theoretical development of the field of biodemography so that we focus on a new generation of biomarkers reflecting molecular and cellular processes that reflect the basic mechanisms of aging, (ii) continue efforts to attract new and promising researchers to the field, and (iii) enhance our Center’s unique role in supporting development, validation, implementation and dissemination of new and better biodemographic measurement protocols. The specific aims of the CBPH will be to: (1) support and foster biodemographic research to understand the multiple and interacting factors that affect population health (with a particular focus on expanding and deepening our understanding of the biological pathways through which experiences and exposures over the life-course impact trajectories of health and how such influences may vary across subgroups and settings); (2) further develop an active biodemographic research community by engaging established and promising junior researchers in a network of scholars who can help advance biodemographic research; (3) offer funding for pilot projects to support cutting-edge biodemographic research; (4) support development and dissemination of new research technologies, methodologies and data through our Research Resource & Dissemination Core and dissemination activities of Administrative Core. Such advances are needed to support development of models of population health that provide much needed evidence for policy planners regarding the most effective points of intervention to improve population health and reduce health disparities. The CBPH has developed the infrastructure, resources and expertise to accomplish its goals and continue its significant leadership role in advancing biodemographic research on aging. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page