UW Center for Translational Muscle Research (Overall Application)

摘要-总体 华盛顿大学（UW）以其在骨骼肌各个方面的卓越成就而享誉国际 生物学，特别是在疾病的机制和转化研究。但目前尚无 集中资源，汇集来自多个部门的所有肌肉调查员， 促进和加快他们的努力。因此，我们建议UW翻译资源中心 肌肉研究（CTMR）提供统一的资源和最先进的方法，以提高骨骼 在华盛顿大学进行肌肉研究拟建中心将提供工具、设施和专业知识， 仅在UW提供，以促进对肌肉病理学的新见解，并将新疗法推向 诊所和市场。这个新中心将提供4个核心（一个行政和三个研究 资源），以提供工具和专业知识，在几个感兴趣的领域，目前的主要调查员。的 行政核心（A）将通过提供试点项目方案来提供方案管理和充实， 为新调查员和更有经验的调查员举办讲习班、系列研讨会、培训和教育机会 研究人员开始研究肌肉。力学和设备核心（B）将提供最新技术水平 在多个整合水平上测量肌肉生物力学，并开发新的成熟测定方法 和早期肌肉的评估。代谢和能量学核心（C）将提供深入研究的工具。 代谢组学、能量学、细胞呼吸和线粒体功能的测量和分析。的 计算和定量分析核心（D）将提供计算和统计工具， 了解疾病，提出新的治疗靶点和了解机制。CTMR将 提供一个环境，以促进使用综合分析，从单分子动力学到肌肉 结构-功能关系，跨学科方法推进骨骼肌疾病研究 和治疗学的发展。

ABSTRACT - Overall The University of Washington (UW) is internationally known for its excellence in all aspects of skeletal muscle biology, especially in mechanistic and translational research of diseases. However, there is currently no centralizing resource that brings together all the muscle investigators from multiple departments for the benefit of facilitating and accelerating their efforts. Therefore we propose the UW Resource Center for Translational Muscle Research (CTMR) to provide a unifying resource and state of the art approaches to enhance skeletal muscle research at the UW. The proposed Center will offer tools, facilities and expertise in a combination available only at the UW to facilitate novel insights to muscle pathologies and move new therapeutics towards the clinic and the marketplace. This new Center will offer 4 cores (one administrative and three research resource) to provide tools and expertise in several areas of interest to current principal investigators. The Administrative Core (A) will provide program management and enrichment by providing a pilot project program, workshops, a seminar series, training and educational opportunities for new investigators and more experienced investigators moving into muscle research. The Mechanics and Devices Core (B) will provide state of the art measurements of muscle biomechanics at multiple levels of integration, and develop new assays for maturation and assessment of early stage muscle. The Metabolism and Energetics Core (C) will provide tools for in depth measures and analysis of metabolomics, energetics, cell respiration and mitochondrial function. The Computational and Quantitative Analysis Core (D) will provide computational and statistical tools for understanding disease, suggesting new therapeutic targets and understanding mechanisms. The CTMR will offer an environment to facilitate using integrative analysis, from single molecule dynamics through muscle structure-function relationships, with interdisciplinary approaches to advance skeletal muscle disease research and therapeutics development.