Academic Leadership Award - The Translational Rehabilitation in Geroscience Initiative

摘要 这个NIA领导奖的长期目标是创造一个强大的，高度可见的，创新的， 可持续的“跨学科转化康复老年科学为重点的研究和教育计划” 作为波士顿大学卓越研究的基石这包括从实验室到早期临床研究， 在高度流行的疾病特异性病症如关节炎、中风和虚弱中则相反。完成其 长期目标，这个领导奖将实现三个具体目标。目标1：扩大知识面 翻译康复和老年科学通过催化研究和教育，通过建立 一个有凝聚力的基础设施，老年科学转化康复倡议（TRIG倡议）。目标二： 创造一个特殊的研究和教育环境，促进成功的发展 多学科翻译康复基于老年科学的研究人员，具有定制的专业知识， 临床前和临床科学。目标3：建立一个试点赠款方案，以支持最有前途的 以老年科学为重点的研究。这些具体目标将通过 候选人对TRIG倡议的领导，打破筒仓，以及与 多学科研究和教育的现有资源。为支持目标1，《触发机制》 将通过积极招募科学家、临床医生和 波士顿的学术和临床机构的受训人员，并定期讨论翻译康复 研究和老年科学主题。为支持目标2，与主要利益攸关方建立跨学科伙伴关系 整个大学和波士顿社区将发展提供丰富的研究和教育 为学生和研究人员提供职业发展的机会，并提供翻译方面的专门知识 康复科学和老年科学（例如，研讨会、讲习班、合作实验室会议、课程。 为了支持目标3，一项年度试点赠款计划将资助跨学科的转化研究， 在基础和早期临床科学之间。这位候选人是国际公认的肌肉男 生理学家，一个导致肌肉减少症的机制的权威，并建立了小鼠的脆弱性 表型评估工具，以便进行转化研究，梳理出虚弱的病因。的 候选人具有必要的科学专业知识，领导技能，临床和研究培训，以及指导 和教学经验，以领导TRIG倡议，实施新的活动和课程，并完成 这一提议的既定目标。通过此次NIA K07领导奖的支持， 令人印象深刻的一系列宝贵的研究和教育资源，通过BU和波士顿地区， 倡议设想积极的跨学科教师和学员从事合作研究，出版物 和教育，建立翻译康复老年科学为基础的研究，最终在计划 项目赠款提交和奖励。

ABSTRACT The long-term objective of this NIA Leadership Award is to create a robust, highly visible, innovative, and sustainable “interdisciplinary translational rehabilitation Geroscience-focused research and education program” as a cornerstone of research excellence at BU. This includes both bench to early-stage clinical investigations and the reverse in highly prevalent disease-specific conditions such as arthritis, stroke, and frailty. To accomplish its long-term objective, this Leadership Award will carry out three specific aims. Aim#1: Expand the knowledge in translational rehabilitation and Geroscience by catalyzing research and education through the establishment of a cohesive infrastructure, the Translational Rehabilitation in Geroscience Initiative (TRIG Initiative). Aim#2: Create an exceptional research and educational environment that fosters development of successful multidisciplinary translational rehabilitation Geroscience-based investigators with customized expertise in preclinical and clinical science. Aim#3: Establish a pilot grant program to support the most promising translational rehabilitation Geroscience-focused studies. These specific aims will be achieved through the candidate’s leadership of the TRIG Initiative, the breaking down of silos, and the meaningful collaboration with the multitude of existing resources for interdisciplinary research and education. In support of Aim 1, the TRIG Initiative will be created through active recruitment of an interdisciplinary group of scientists, clinicians, and trainees across Boston’s academic and clinical institutions and regular discussions on translational rehabilitation research and Geroscience themes. In support of Aim 2, interdisciplinary partnerships with key stakeholders across the entire university and Boston community will be developed to offer rich research and educational opportunities for the career development of students and investigators with tailored expertise in translational rehabilitation science and Geroscience (e.g., seminars, workshops, collaborative laboratory meetings, courses.) In support of Aim 3, an annual pilot grant program will fund multidisciplinary, translational research that spans between basic and early-stage clinical sciences. The candidate is an internationally recognized muscle physiologist, a leading authority on mechanisms contributing to sarcopenia, and established the mouse frailty phenotype assessment tool in order to conduct translational research to tease out the etiology of frailty. The candidate has the necessary scientific expertise, leadership skills, clinical and research training, and mentoring and teaching experience to lead the TRIG Initiative, implement new activities and curriculum, and accomplish the stated aims of this proposal. Through the support of this NIA K07 Leadership Award and leveraging an impressive array of valuable research and educational resources through BU and the Boston area, the TRIG Initiative envisions active interdisciplinary faculty and trainees engaging in collaborative research, publications and education, building translational rehabilitation Geroscience-based research that culminates in program project grant submission and awards.