Administrative Core

项目摘要/摘要(行政核心) 行政核心(AC)将提供全面的行政和组织监督以及 拟议的HHEAR枢纽的管理。HHEAR枢纽AC将协调管理 科学、组织、财务和合同活动，并促进HHEAR之间的沟通 枢纽成员。AC将与HHEAR协调中心(HHEAR CC)进行沟通和协调 HHEAR中心与数据存储库分析和科学中心(DAC)的所有活动。《赫尔》 HUB AC将组织与CC和HHEAR项目客户的磋商，为研究提供投入 设计、样品收集、储存、材料需求和装运，制定工作报表和预算， 并确保数据存储。HHEAR Hub AC将确保员工参与电话会议和面对面 与HHEAR网络举行会议，讨论和共享方法、工作流程并开发数据存储 要求。这将包括参加HHEAR Hub工作组、环试验和跨实验室 比较。HHEAR Hub AC将为新方法提供一个开发和共享信息的场所 在这个HHEAR中心和整个HHEAR财团的数据捕获或数据解释方面。空调将会 确保我们的沟通和方法得到改进，以满足客户的需求。管理委员会亦会确保 实验室信息系统(LIMS)用于跟踪项目的所有方面，从最初的客户开始 通过样品接收、数据分析和报告进行沟通。HHEAR集线器空调将确保 HHEAR Hub为工作流程中的所有步骤制定了协议和质量控制措施，并且质量 审计由独立的工作人员进行。咨询委员会将通过以下方式评估研究界的需求： 召开财团会议、流行病学会议、召开座谈会，收集利益相关者的意见。 HHEAR中心将由多名PI(MPI)领导，Timothy Fennell博士(RTI)曾担任 NIEHS资助的儿童健康暴露分析资源(CHEAR)中心，过去3年； 苏珊·萨姆纳(北卡罗来纳大学教堂山分校)，曾担任NIH东部地区综合体的PI 自2012年以来的代谢组学资源核心(ERCMRC)；MPI杜秀霞博士(北卡罗来纳大学夏洛特分校)，他是 美国国立卫生研究院共同基金代谢组学计划第二阶段。Fennell博士将指导HHEAR Hub的空调，Will 成为选举委员会有投票权的成员，并将领导区议会。萨姆纳博士将领导UARC，杜博士将领导 计算展示体(CE)工作流。所有MPI都将在SC中服务，并成为有投票权的成员。

Project Summary/ Abstract (Administrative Core) The Administrative Core (AC) will provide overall administrative and organizational oversight and management of the proposed HHEAR Hub. The HHEAR Hub AC will coordinate the management of the scientific, organizational, financial, and contractual activities, and facilitate communication among the HHEAR Hub members. The AC will communicate with the HHEAR Coordinating Center (HHEAR CC) and coordinate all of the HHEAR Hub activities with the Data Repository Analysis and Science Center (DAC). The HHEAR Hub AC will organize consultations with the CC and the HHEAR program clients to provide input for study design, sample collection, storage, material needs, and shipment, develop statements of work and budgets, and ensure data deposition. The HHEAR Hub AC will ensure staff participate in conference calls and in-person meetings with the HHEAR Network to discuss and share methods, workflows, and to develop data deposition requirements. This will include participation in the HHEAR Hub working groups, ring trials, and cross-laboratory comparisons. The HHEAR Hub AC will provide a venue to develop and share information for new approaches in data capture or data interpretation in this HHEAR Hub, and across the HHEAR consortium. The AC will ensure that our communications and methods are refined to meet clients’ needs. The AC will also ensure that a Laboratory Information System (LIMS) is used to track all aspects of projects, from initial client communication through sample receipt, data analysis, and reporting. The HHEAR Hub AC will ensure that the HHEAR Hub has protocols and quality control measures in place for all steps in the work flow, and that quality audits are made by independent staff. The AC will assess the needs of the research community by attending consortia meeting, epidemiology conferences, and holding symposia to gather stakeholders’ opinions. The HHEAR Hub will be led by Multiple PI (MPI), Dr. Timothy Fennell (RTI), who has served as the PI of a NIEHS-funded Children’s Health Exposure Analysis Resource (CHEAR) Hub for the past 3 years; MPI Dr. Susan Sumner (UNC Chapel Hill), who has served as the PI of the NIH Eastern Regional Comprehensive Metabolomics Resource Core (ERCMRC) since 2012; and MPI Dr. Xiuxia Du (UNC Charlotte), who is a PI in the Phase 2 NIH Common Fund Metabolomics Program. Dr. Fennell will direct the AC for the HHEAR Hub, will be the voting member of the EC, and will direct the DC. Dr. Sumner will direct the UARC, and Dr. Du will direct the Computational Exposome (CE) workflows. All MPIs will serve on the SC and be voting members.