Data Analysis Core

项目摘要 VU-BIOMIC数据分析核心(DAC)同时面临分析前和分析方面的挑战。这个 DAC的研究人员具有广泛的处理高维成像质量的经验 光谱分析数据集，甚至在处理此类数据的新方法领域处于领先地位。此外，DAC 该团队开创了将高空间分辨率显微镜和三维数据集与 IMS。然而，BIOMIC将要求DAC设计一个平台，该平台集成了所有分析前和 将分析计算方法转化为能够处理数据的完整计算平台 由表征流水线高效地生成。开展的所有工作背后的主要推动力将是 重建和后续分析的自动化。这将允许即插即用分析新的 生成的数据集。由于实验工作流程是扩展的，DAC很重要 提供指标的快速反馈以跟踪数据质量，并提供导致生物学洞察的分析。

Project Summary The VU-BIOMIC Data Analysis Core (DAC) is tasked with both pre-analytical and analytical challenges. The investigators of the DAC have broad range of experience working with high-dimensional imaging mass spectrometry data sets, even leading the field in new methodologies to process such data. In addition, the DAC team has pioneered methods to combine high spatial resolution microscopy and 3-dimensional data sets with IMS. However, BIOMIC will require that the DAC architect a platform that integrate all of the pre-analytical and analytical computational approaches into a complete computational platform capable of processing the data generated by the Characterization pipeline efficiently. A primary driving force behind all work carried out will be automation of the reconstruction and subsequent analysis. This will allow plug-and-play analysis of new datasets as they are generated. As the experimental workflow is expansive, it is important that the DAC provide rapid feedback of metrics to track data quality and provide analyses that lead to biological insight.