High-performance compact 3T MRI: Technical optimization for advanced brain imaging

项目总结/摘要 一种突破性的轻型、紧凑型3 T MR扫描仪已被证明具有 700 T/m/s转换速率，以80 mT/m振幅运行），转换速率比全身快3.5倍 核磁共振。该计划的下一阶段将通过多学科提供关键的神经成像工具。 马约诊所和通用电气全球研究部之间的合作。这项拟议的工作包括在图像重建，系统伪影校正和脉冲序列编程，利用进一步的技术发展， 紧凑型3 T的独特高性能。 该项目的具体目标是： ·目标1）开发紧凑型3 T上的回波平面成像（EPI）核心技术 ·目标2）开发新的基于MRI的连接组学 ·目标3）开发高分辨率MR弹性成像（MRE）脑硬度测量 目标1侧重于改进紧凑型3 T系统的EPI，以最大限度地利用其独特的梯度 转换速率和比吸收率（SAR）优势。与这一目标相关的具体任务包括：开发基于模型的重建，实时系统补偿以消除伴随的场伪影， 脉冲序列开发用于非常快速的解剖成像的分段EPI，并通过利用SAR优势提高同步多层（SMS）的效率。 目的2利用紧凑的3 T的显着减少的敏感性伪影在内侧颞叶的区域，使无任务的功能磁共振成像自发coactiveillance研究的整个大脑，包括海马，这是中央阿尔茨海默氏病（AD）的研究。 目标3介绍了紧凑型3 T的高性能梯度如何首次实现3D梯度 基于回波的MR弹性成像（3DMRE）。这将使所采集的体素大小减少8倍， 与我们目前通过全身核磁共振成像获得的2DMRE进行对比。这有重要的应用，不仅是 肿瘤切除术的术前计划，而且还可能开发新的生物标志物用于研究神经变性疾病，如AD。新的3DMRE技术将在与Aim相同的患者队列中进行研究 2.我们相信，在紧凑型3 T MR平台上大大提高的空间分辨率和扫描效率将使 新的临床和神经科学应用，用于评估脑部疾病管理，包括创伤性脑 损伤、肿瘤治疗计划和神经退行性疾病。

PROJECT SUMMARY/ABSTRACT A breakthrough lightweight, compact 3T MR scanner has been demonstrated to have gradient performance of 700 T/m/s slew rate, operating at 80 mT/m amplitude), which is a slew rate that is 3.5x faster than whole-body MRIs. The proposed next phase of the program will deliver key neuroimaging tools through a multi-disciplinary collaboration between Mayo Clinic and GE Global Research. This proposed work includes further technical development in image reconstruction, systems artifact correction, and pulse sequence programming that exploits the unique, high-performance capabilities of the compact 3T. The Specific Aims of the project are to: · Aim 1) Develop Core Technologies for Echo Planar Imaging (EPI) on the Compact 3T · Aim 2) Develop New MRI-based Connectomics · Aim 3) Develop High-Resolution MR Elastography (MRE) Brain Stiffness Measurement Aim 1 focuses on improving EPI on the compact 3T system to maximally capitalize on its unique gradient slew rate and specific absorption rate (SAR) advantages. Specific tasks related to this aim include: the development of model-based reconstructions, real-time system compensation to eliminate concomitant field artifacts, pulse sequence development for segmented EPI for very fast anatomical imaging, and improved efficiency for simultaneous multislice (SMS) by exploiting the SAR advantages. Aim 2 exploits the compact 3T's dramatically reduced susceptibility artifacts in the region of the medial temporal lobe to enable task-free fMRI spontaneous coactiviation studies of the entire brain, including the hippocampus, which is central to the study of Alzheimer's disease (AD). Aim 3 describes how the compact 3T's high-performance gradients enable, for the first time, 3D gradient echo-based MR elastography (3DMRE). This will enable an 8x reduction in the acquired voxel size compared with the 2DMRE currently acquired with our whole-body MRIs. This has important applications, not-only to pre-surgical planning for tumor resection, but also to potentially develop new biomarkers for the study of neurodenegerative disease, such as AD. The new 3DMRE technique will be studied in the same patient cohort as Aim 2. We believe vastly improved spatial resolution and scan efficiency on the compact 3T MR platform will enable new clinical and neuroscience applications for assessing brain disease management, including traumatic brain injury, tumor treatment planning, and neurodegenerative diseases.