Biological Mechanisms Core-RC-2

资源核心2（RC 2）生物机制核心：项目摘要 查明身体虚弱和与年龄有关的脆弱性的病因仍然是一项重大挑战， 老年学研究应对这一挑战的关键是更好地了解 导致脆弱性的潜在生物学基础以及关键生物学途径的识别 制定可能有助于预防或减轻脆弱和丧失独立性的干预措施。目标 约翰霍普金斯老年美国人独立中心（OAIC）的生物机制核心（RC-2）是 使下一代的弱点相关的病因学发现，并促进这些翻译 临床相关的诊断，预防和治疗模式的发现。核心实现了这一点 通过提供高质量的生物测量专业知识、技术和基础设施 必须实现这一目标。为了全面涵盖生物和测量 我们拥有研究虚弱相关病因学所需的专业知识，我们聘请了一个具有相当大的领导团队， 生物学和翻译专业知识以及几位内部顾问，他们带来了关键的额外知识， 专业知识、受训人员辅导和基础设施。RC-2的具体目标是：1）提供 先进的科学专业知识，基础设施和技术，以促进生物和 与虚弱相关的病因学研究，2）提供来自人类受试者和来自 测试与虚弱相关的假设所需的动物模型，3）促进生物学的翻译 将研究结果纳入干预措施或以预防为重点的临床研究，4）提供培训，指导， 指导有前途的初级研究人员了解影响脆弱性的生物学机制，以及5）提供 RC-2相关科学和活动的机构和外部可见度。这些宣传工作将 如第8节所述，新的信息传播核心（IDC）进一步促进了这一进程。我们的目标将 通过核心领导人与他们的实验室之间的密切沟通， 与其他OAIC核心建立合作伙伴关系，并聘请高度相关的专家顾问 线粒体测量、代谢组学、小鼠模型开发、 诊断目的，以及与药物开发相关的纳米技术。通过提供这些资源，RC-2 将促进高质量的研究，阐明临床相关的生物学途径，基础脆弱， 相关的干预措施，有望减轻脆弱，相关的条件，和独立性的丧失。

Resource Core 2 (RC2) Biological Mechanisms Core: Project Summary The identification of the etiologies of frailty and age-related vulnerability remains a crucial challenge for gerontological research. Key to this challenge are the development of a better understanding of the underlying biological basis that contributes to frailty and the identification of key biological pathways for the development of interventions that might help prevent or alleviate frailty and loss of independence. The goal of Johns Hopkins Older Americans Independence Center (OAIC) Biological Mechanisms Core (RC-2) is to enable the next generation of frailty-related etiological discovery and to promote the translation of these discoveries into clinically relevant diagnostic, preventive, and treatment modalities. This core achieves this through the provision of high-quality biological measurement expertise, technologies, and infrastructure necessary to attain this goal. In order to comprehensively encompass the biological and measurement expertise necessary to study frailty-related etiology, we have engaged a leadership team with considerable biological and translational expertise as well as several internal consultants who bring crucial additional expertise, mentorship for trainees, and infrastructure to RC-2. The specific aims of RC-2 are to: 1) provide state of the art scientific expertise, infrastructure, and technology necessary to advance biological and etiological research related to frailty, 2) provide access to biological samples from human subjects and from animal models necessary to test hypotheses related to frailty, 3) facilitate the translation of biological findings into interventions or prevention-focused clinical studies, 4) provide training, mentorship, and guidance to promising junior investigators around biological mechanisms that impact frailty, and 5) provide institutional and external visibility for RC-2 related science and activities. These visibility efforts will be further facilitated by a novel Information Dissemination Core (IDC) as described in section 8. Our aims will be accomplished through close communication between the core leaders and their laboratories, close partnership with the other OAIC cores, and the engagement of expert consultants in the highly relevant areas of mitochondrial measurement, metabolomics, mouse model development, nanotechnologies for diagnostic purposes, and nanotechnology related to drug development. By providing these resources, RC-2 will foster high quality research that elucidates clinically relevant biological pathways that underlie frailty and related interventions that hold promise to attenuate frailty, related conditions, and the loss of independence.