Child Health Research Career Development Award (CHRCDA) Program at Children's National

摘要 儿童健康研究职业发展奖(CHRCDA)项目的目的 国家医院(CNH)是为了促进成功的基础、翻译和临床研究的发展 初级教员在儿科的职业生涯跨越T0到T4的光谱。该计划的基本原理是 虽然使用分子生物学、生物医学工程和转化科学的机会很多 推进儿科疾病的治疗，全面的科学知识和实践经验 在年轻的儿科医生研究人员中，利用这些机会所需的知识往往是不足的 他们最近完成了较长时间的临床培训。CNH的CHRCDA通过以下方式满足这一需求 为初出茅庐的科学家在他们最初的学术任命期间提供足够的保护时间。在我们的 计划，学者将：1)参加与其相关的基础、翻译或临床科学领域的课程 研究；2)学习最先进的实验室和计算方法；3)开发初步数据 在既定的和承诺的导师的监督下，这将导致独立的NIH提交 批准申请；以及4)学习有效地促进基础、翻译和临床方面的成就 关于改善儿童健康的研究。为了实现这些目标，CHRCDA学者将 在资深调查人员/导师的指导下，至少花费75%的精力来磨练这些技能 2-4年(取决于过去的经验和调查领域)。在此期间，每一位 上述任务将以系统的方式处理，包括参加研究的核心课程 方法论和生物统计学，在负责任地进行研究方面的培训，以及在 在高级调查人员的监督下，研究越来越独立。我们每年将资助三名学者 助理教授级别，具体目标是通过积极的外联活动加强学者多样性 和招聘。我们将有四个科学亲和组的21名高级导师：神经科学，分子 遗传学、癌症和免疫学，以及生物医学工程。行政结构将包括两个 首席调查人员/项目主任、培训主任、执行委员会和外部 咨询委员会。这个项目的结果将由学者们的产品来衡量 后来的学术生涯：出版和独立的外部资助。在此续订申请中 我们推出了几项创新，包括：扩大资助研究，将T2-T4科学与 招募合适的导师干部，新的流水线计划，以增加我们的候选人库 包括两个R38奖项，用于资助儿科住院医生的研究，重大资本投资包括 新的儿童国家研究和创新园区，适应独特的挑战 新冠肺炎大流行期间的培训，对多样性的更大承诺，以及纳入初级导师 和我们的资深导师一起“培训训练师”。

ABSTRACT The purpose of the Child Health Research Career Development Award (CHRCDA) Program at the Children’s National Hospital (CNH) is to facilitate the development of successful basic, translational, and clinical research careers for junior faculty members in pediatrics across the T0-T4 spectrum. The rationale for the program is that while many opportunities exist to use molecular biology, biomedical engineering, and translational science to advance treatment of pediatric diseases, the comprehensive scientific knowledge and practical experience that are required to capitalize on these opportunities are often deficient among young pediatrician-investigators who have recently finished extended periods of clinical training. The CHRCDA at CNH addresses this need by providing sufficient protected time for nascent scientists during their initial academic appointment. In our program, scholars will: 1) take coursework in basic, translational, or clinical science areas relevant to their research; 2) learn state-of-the art laboratory and computational methodologies; 3) develop preliminary data under the supervision of established and committed mentors that will lead to submission of independent NIH grant applications; and 4) learn to effectively advance accomplishments in basic, translational, and clinical research into improvements in child health. In order to accomplish these goals, the CHRCDA scholars will spend at least 75% effort honing these skills under the mentorship of established investigators/mentors over a 2-4 year period (depending on past experience and area of investigation). During this period, each of the above tasks will be addressed in a systematic fashion, including participation in a core curriculum in research methodology and biostatistics, in training in responsible conduct of research, and in performance of increasingly independent research under supervising senior investigators. We will fund three scholars annually at the Assistant Professor level with a specific goal of enhancing scholar diversity through aggressive outreach and recruitment. We will have 21 senior mentors in four scientific affinity groups: neuroscience, molecular genetics, cancer and immunology, and biomedical engineering. The administrative structure will include two Principal Investigators/Program Directors, a Training Director, an Executive Committee, and an external Advisory Committee. The outcomes of this program will be measured by the products of the scholars’ subsequent academic careers: publications and independent external grant support. In this renewal application we introduce several innovations including: expansion of funded research to include T2-T4 science with recruitment of a cadre of appropriate mentors, new pipeline programs to increase our pool of candidates including two R38 awards to fund research among pediatric residents, significant capital investments including the new Children’s National Research and Innovation campus, adaptations for the unique challenges of training during the COVID-19 pandemic, an expanded commitment to diversity, and inclusion of junior mentors to be paired with our senior mentors to “train the trainers.”