MICRORNA PREDICTORS OF OESOPHAGEAL TUMOUR RESPONSE TO CHEMOTHERAPY AND RADIOTHERAPY

放化疗（CRT）用于食管癌手术切除前的治疗，以及未接受手术的患者。然而，对许多人来说，这是不成功的，会产生副作用，没有临床效果，并延迟手术。microrna是控制细胞功能的小分子。该项目将确定能够预测癌症对CRT反应的miRNA标记物，这将有助于个体化治疗的临床决策。

Chemoradiotherapy (CRT) is used for the treatment of oesophageal cancer before surgical resection, and for patients not undergoing surgery. However, it is unsuccessful for many, causing side effects, no clinical gain, and delaying surgery. MicroRNAs are small molecules that control cellular functions. This project will identify miRNA markers which are able to predict cancer response to CRT, and this will help clinical decision making for individualized treatment.