Core A-Administrative Core

核心A -项目摘要 目前胸主动脉瘤（TAA）的治疗通常包括降低血压的药物， 外科手术因此，TAA存在未满足的医疗需求。在本申请中， 机械转导作为胸主动脉瘤的治疗靶点，我们提出了一种新的 TAA的启动和促进机制是基于细胞对机械变化的感知， 他们的环境。这项计划拨款将集中在阐明我们的假设是否正确。核心A， 行政核心将负责对本计划项目的所有方面进行行政监督 格兰特（PPG）。因此，核心A将通过组织联合实验室来监测和促进整体科学进展。 会议、年度务虚会、电子数据交换、执行委员会成员会议，以及 与科学顾问委员会（SAB）和内部顾问委员会（IAB）的互动。核心A将 监控各个组成部分的财务交易，并确保遵守NIH指南。 行政核心还将监测该计划中与保险有关的所有其他监管要素 各个组件保持合规性，并将向NIH报告任何问题、变化或新情况 举措行政核心还将每年组织并向NIH提供一份进度报告， 作为供资期结束时的最后进度报告，根据 组件PI。

Core A - Project Summary Current treatment for thoracic aortic aneurysms (TAA) usually consists of drugs to reduce blood pressure or surgical intervention. Thus, TAAs present an unmet medical need. In this application, Altered Mechanotransduction as a Therapeutic Target for Thoracic Aortic Aneurysm, we propose a novel mechanism for the initiation and promotion of TAAs based upon cell sensing of the mechanical changes in their environment. This programmatic grant will focus on elucidating whether our hypothesis is correct. Core A, the Administrative Core, will be in charge of administrative oversight of all aspects of this Program Project Grant (PPG). As such Core A will monitor and promote the overall scientific progress by organizing joint lab meetings, annual retreats, electronic exchange of data, Executive Committee member meetings, and interactions with both the Scientific Advisory Board (SAB) and the Internal Advisory Board (IAB). Core A will monitor the financial transactions of the individual components and insure that NIH guidelines are followed. The Administrative Core also will monitor all other regulatory elements of the program with respect to insuring that the individual components remain in compliance and will report to the NIH any problems, changes, or new initiatives. The Administrative Core will organize and provide to the NIH a Progress Report each year, as well as a final Progress Report at the end of the funding period, based upon the individual reports supplied by the component PIs.