Microscopy and Histopathology Core B

项目摘要 显微镜和组织学核心B的使命是为HDDC成员提供基本的， 先进的显微镜设备，服务和培训，图像处理资源，组织学和 组织病理学支持，并支持实验设计和科学分析，这是必不可少的 消化系统疾病的研究。 核心B是HDDC的一个长期组成部分，是三个 独立的基于成像的核心，具有自己的财务结构，每个核心由一名董事领导。的 三个站点是贝斯以色列女执事医疗中心（站点A），波士顿儿童医院（站点B），和 布里格姆妇女医院（C站点）。这三个核心站点在物理上彼此靠近， 由一个核心主管统一，他负责监督每个卫星核心与HDDC及其 会员资格该基础设施通过提供成像设备极大地有利于HDDC成员 和专业知识，同时还提供放大选项， 实验室发起的研究计划，并使新的实验方法。这种基础设施 还允许成功整合其他哈佛核心设施，专门从事先进的 仪器仪表 在过去的5年资助周期中，为核心B提供了9项服务，共有39名HDDC主要成员 和13个使用核心B的附属会员。核心B总体平均记录了4，200次计费服务 小时/年和16，858总计费小时在过去4年赠款周期（2015-2019）与95（小学） 使用），42（二次使用）和1（三级使用）的原始文件出现的核心B利用。HDDC 通过将HDDC的服务成本降低25%或更多，支持大幅增加赠款 成员在过去的赠款周期中，新的创新和设备更新特别使 电子显微镜和共聚焦显微镜服务及其用户。 在下一个赠款周期，核心B将提供同样的9项服务，64个成员表示， 有兴趣使用Core B服务。在先进的显微镜类别，一个新的服务，在高 HDDC成员将获得高分辨率三维电子显微镜。HDDC的折扣服务 主要成员将继续扩大赠款美元和优先访问所有HDDC成员应 在下一个赠款周期，利用尖端仪器和专门知识提高生产力。

Project Summary The mission of the Microscopy and Histopathology Core B is to provide HDDC members with basic and advanced microscope equipment, services and training, image processing resources, histology and histopathology support, and support for experimental design and scientific analysis that are essential for research in the digestive diseases. Core B, which is a long-standing component of the HDDC, is a successful collaboration among three independent imaging-based cores with their own financial structure that are each led by a director. The three sites are Beth Israel Deaconess Medical Center (Site A), Boston Children’s Hospital (Site B), and Brigham and Women’s Hospital (Site C). The three core sites are physically close to one another and unified by a Core Director who oversees the relationship of each satellite core with the HDDC and its membership. This infrastructure greatly benefits the HDDC membership by providing imaging equipment and expertise in locations highly populated with HDDC users while also providing options to amplify investigator-initiated research programs and enable new experimental approaches. This infrastructure also allows for the successful integration of other Harvard-based core facilities specializing in advanced instrumentation. Nine services were offered for Core B in the past 5-year grant cycle with 39 HDDC Principal Members and 13 Affiliate Members using Core B. Overall Core B recorded on average 4,200 billable service hours/year and 16,858 total billable hours over the last 4 year grant cycle (2015-2019) with 95 (primary use), 42 (secondary use), and 1 (tertiary use) original papers emerging from Core B utilization. HDDC support significantly extended grant dollars by reducing the cost of services by 25% or more for HDDC members. New innovations and equipment updates in the past grant cycle benefited, in particular, the electron microscopy and confocal microscopy services and their users. In the next grant cycle, the same nine services will be offered in Core B with 64 members indicating an interest in using Core B services. In the advanced microscopy category, one new service in high resolution 3-D electron microscopy will be available to HDDC members. Discounted services for HDDC Principal Members will continue to extend grant dollars and priority access for all HDDC members should facilitate greater productivity with cutting-edge instrumentation and expertise in the next grant cycle.