Chicago Stroke Trials Consortium

中风是美国死亡和残疾的主要原因。尽管科学和技术 尽管取得了一些进展，但对中风患者的临床结局益处的转化有限。自2013年以来，A 中风试验网络一直致力于开发突破性的中风治疗方法， 重点是快速执行临床试验，样本量充足，招募人数充足， 完整性以及各站点之间严格统一的基础设施。 本申请是为了响应最近NINDS对区域协调卒中中心的要求 (RCC)NINDS卒中试验网络（PAR-17-276）。芝加哥卒中试验联盟（CSTC） 由西北大学（NU）的RCC提供的数据已经成为NIH StrokeNet的一个组成部分。在这次更新中， 我们将我们的网络扩展到包括芝加哥和密尔沃基大都市区的12个中心： 西北纪念医院，卢里儿童医院，雪莉瑞安能力实验室，（所有NU的麦高的一部分 医学中心）、芝加哥大学、拉什大学医学中心、洛约拉大学芝加哥分校、 伊利诺伊大学芝加哥分校、威斯康星州医学院、赫克顿医学研究所 研究/John H.小斯特罗格库克县医院，中央杜佩奇医院，西北社区 爱德华·海因斯（Edward Hines，Jr.）退伍军人医院我们已争取到机构支持，包括达成协议， 利用联合机构审查委员会流程（中央IRB）和主试验协议，确保快速 我们每个参与研究中心未来试验的实施。RCC旨在将联合收割机资源， 多样化的教师与中风的专业知识，并获得中风患者的多种族人口，从 从儿童到老年人，从急性治疗到康复。CSTC将参与急性中风， 康复和预防试验，并拥有血管神经病学，神经外科， 神经重症监护、神经放射学、介入神经放射学、神经康复、小儿神经病学，以及 急诊医学聚集的研究人员具有中风研究各个方面的背景， 在许多最近完成和正在进行的NIH和行业赞助的试验中担任领导角色。该财团 有一个合并的地理转诊基础，包括近1000万人，并有历史， 在临床和科学方面的合作。从我们医院广阔的地理范围来看， 他们的资源和调查人员，以及在最初的授予期间对StrokeNet的实质性贡献， CSTC是唯一有资格继续提供多样化的中风患者人群， 为StrokeNet试验提供多学科和多机构的专业知识和领导，并确保对以下人员进行指导： 寻求中风学术生涯的学员和初级教师。

Stroke is a leading cause of death and disability in the United States. Despite scientific and technological advances, there has been limited translation into clinical outcome benefits for stroke patients. Since 2013, a cohesive and integrated Stroke Trials Network has been working to develop breakthrough stroke treatments with an emphasis on rapid execution of clinical trials with sufficient sample sizes, robust enrollment, timely completion, and rigorous and uniform infrastructure across sites. This application is in response to the recent NINDS request for Regional Coordinating Stroke Centers (RCC) in the NINDS Stroke Trials Network (PAR-17-276). The Chicago Stroke Trials Consortium (CSTC) led by the RCC at Northwestern University (NU) has been an integral part of the NIH StrokeNet. In this renewal application, we expand our network to include 12 centers in the Chicago and Milwaukee metropolitan areas: Northwestern Memorial Hospital, Lurie Children's Hospital, Shirley Ryan Ability Lab, (all part of NU's McGaw Medical Center), the University of Chicago, Rush University Medical Center, Loyola University Chicago, University of Illinois at Chicago, Medical College of Wisconsin, the Hektoen Institute for Medical Research/John H. Stroger, Jr. Hospital of Cook County, Central Dupage Hospital, Northwest Community Hospital, and Edward Hines, Jr. VA Hospital. We have enlisted institutional support including agreements to utilize a federated institutional review board process (central IRB) and master trial agreements to ensure rapid implementation of future trials from each of our participating sites. The RCC aims to combine resources, diverse faculty with stroke expertise, and access to a multi-ethnic population of stroke patients spanning from children to elderly and from acute treatment to rehabilitation. The CSTC will participate in acute stroke, rehabilitation, and prevention trials, and has expertise from investigators in vascular neurology, neurosurgery, neurocritical care, neuroradiology, interventional neuroradiology, neurorehabilitation, pediatric neurology, and emergency medicine. The amassed investigators have backgrounds in all aspects of stroke research and leadership roles in many recently completed and ongoing NIH and industry-sponsored trials. The consortium has a combined geographic referral base encompassing almost 10 million people and has a history of collaboration in clinical and scientific endeavors. Drawing from the vast geographic reach of our hospitals, their resources and investigators, and substantial contributions to StrokeNet during the initial award period, the CSTC is uniquely qualified to continue to deliver a diverse stroke patient population, provide consolidated multi-disciplinary and multi-institutional expertise and leadership for StrokeNet trials, and ensure mentoring for trainees and junior faculty seeking academic careers in stroke.