Pittsburgh Older Americans Independence Center

整体组件项目摘要/摘要 匹兹堡克劳德·D·佩珀老年美国独立中心(OAIC)的总体目标，由 自2004年以来，都是为了解决改善机动性、平衡性和跌倒风险的迫切需求，这两个方面都通过改进 通过制定预防和治疗干预措施，了解其原因。有了这个 我们还将把我们的工作扩展到新的和高潜力的领域，并为我们的 活动和核心。 未来5年的具体目标是： 1)促进多学科研究，阐明年龄的原因、后果和管理- 机动性和平衡性方面的相关变化。 2)进一步将我们的工作扩展到两个高潜力领域：a)翻译调查，以检查相互作用 在分子、信号系统、细胞及其细胞器和组织水平上的多个系统之间， 因为它们影响活体的流动性和平衡性，以及b)对个人老年人健康的影响 系统、社区和长期护理干预措施，以增强流动性和平衡性。 3)培训来自多个学科的年轻研究人员，使其成为与年龄相关的流动性和 在充满活力的协作环境中平衡问题，并通过 协作式基础和临床科学团队指导。 4)作为调查人员、研究方案、机构、OAIC和 在老年人的机动性和平衡性方面向公众提供帮助。 我们的成就和计划建立在我们的基本价值观之上：1)具有凝聚力的主题 多种方法和机会来解决知识中的关键差距，2)承诺 多学科研究，3)成长和发展的稳定组织，以及4)严谨的准备 未来的调查人员和领导人。 为了实现这些目标，我们的OAIC围绕7个核心构建。除了领导层和行政层 核心(LAC)和研究教育部分(REC)，我们有一个试点和探索性研究核心 (PESC)和4个资源核心：1)临床和人口结果核心(CPOC)，2)综合 系统核心(ISC)，3)数据管理、分析和信息学核心(DMAIC)，本周期新增一个 运动与衰老生物学核心(BMAC)。在续签的第一年，我们将支持3名胡椒学者， 5个试点项目和4个发展项目，说明了我们工作的范围和创新。

Overall Component Project Summary/Abstract The overall goals of the Pittsburgh Claude D. Pepper Older American Independence Center (OAIC), funded since 2004, are to address the critical need to improve mobility, balance and falls risk, both through improved understanding of their causes and through development of preventive and therapeutic interventions. With this renewal we also will extend our work into new and high potential areas and bring several innovations to our activities and Cores. Specific aims for the next 5 years are to: 1) Promote multidisciplinary research that will elucidate the causes, consequences and management of age- related changes in mobility and balance. 2) Further extend our work into two high potential areas: a) translational investigations to examine interactions between multiple systems at the level of molecules, signaling systems, cells and their organelles, and tissues, as they impact mobility and balance in living organisms, and b) impact on individual older adults of health system, community and long-term care interventions to enhance mobility and balance. 3) Train young investigators from multiple disciplines to become national leaders in age-related mobility and balance problems in a vibrant, collaborative environment and build a translational sciences workforce through collaborative basic and clinical sciences team mentoring. 4) Serve as a champion and invaluable resource for investigators, research programs, institutions, OAICs and the public in the area of mobility and balance in older adults. Our accomplishments and plans build on our fundamental values: 1) a cohesive theme that accommodates multiple approaches and opportunities to address critical gaps in knowledge, 2) a commitment to multidisciplinary research, 3) a stable organization that grows and evolves, and 4) rigorous preparation of future investigators and leaders. To accomplish these aims, our OAIC is built around 7 cores. In addition to the Leadership and Administrative Core (LAC) and a Research Education Component (REC), we have a Pilot and Exploratory Studies Core (PESC) and 4 resource Cores: 1) a Clinical and Populations Outcomes Core (CPOC), 2) an Integrative Systems Core (ISC), 3) a Data Management, Analysis and Informatics Core (DMAIC) and, new for this cycle, a Biology of Mobility and Aging Core (BMAC). In the first year of the renewal, we will support 3 Pepper Scholars, 5 pilot projects, and 4 developmental projects that illustrate the scope and innovation of our work.