Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping

7.项目摘要 心力衰竭（HF）是一个主要的公共卫生问题，估计有620万美国人患有 HF和每年超过100万的新病例。HF患者的心脏质量显著降低， 这些患者的死亡率很高，住院和心血管不良后果的风险很高。人们越来越 认识到心脏磁共振成像（CMR）用于评估HF患者的临床效用。 虽然CMR越来越多地用于HF的评估，但仍存在许多广泛的障碍。 接受并使用CMR。目前的临床研究需要40分钟到1小时， 需要患者完成大约40次持续时间为10-15秒的单独屏气。有强有力 通过创建简化和稳健的自由呼吸、非ECG，有可能提高CMR在HF中的临床效用 门控技术，这是直接执行。这也将改善患者的体验， 缩短了研究时间并消除了对HF患者特别困难的屏气的需要。 为了解决当前临床技术的这些局限性，我们建议开发和验证一种 技术，Cine和T1标测呼吸和心脏自门控螺旋采集（CAT-SPARCS）， 其将在<5分钟的FB非ECG门控采集中同时执行电影和T1标测。 在造影前后应用该技术将能够全面评估心脏功能， 原生T1，LGE和ECV在15分钟内。本提案的具体目标是：（1）开发二维CAT- SPARCS技术可在自由呼吸心脏检查期间同时采集电影、T1标测图和LGE图像 自门控采集，（2）扩展2D CAT-SPARCS，以提供全心脏同步采集， 采用同步多层（SMS）和3D螺旋采集技术的电影、T1标测和LGE图像， 和（3）验证CAT-SPARCS技术与临床金标准屏气ECG门控临床 技术在正常受试者和正在评估HF的患者中。成功完成这项赠款将导致 在开发和验证同时进行T1标测和电影成像的高效技术方面， 这将证明高精度和可重复性，显著缩短CMR检查。

7. Project Summary Heart failure (HF) is a major public health concern with an estimated 6.2 million Americans suffering from HF and greater than 1 million new cases per year. Patients with HF have significantly reduced quality of life and are at high risk for hospitalization and adverse cardiovascular outcomes. There is a growing recognition of the clinical utility of cardiac magnetic resonance imaging (CMR) for assessing patients with HF. While there is growing utilization of CMR for evaluation of HF, there remain a number of barriers to widespread acceptance and utilization of CMR for this application. Current clinical studies take 40 min to an hour and require the patient to complete about 40 separate breath-holds of 10-15 second duration. There is strong potential to improve the clinical utility of CMR in HF by creating simplified and robust free-breathing, non-ECG gated techniques, which are straightforward to perform. This would also improve the patient experience by shortening the study and eliminating the need for breath-holding, which is particularly difficult for HF patients. To address these limitations of current clinical techniques, we propose to develop and validate a technique, Cine And T1 mapping SPiral Acquisition with Respiratory and Cardiac Self-gating (CAT-SPARCS), which will simultaneously perform cine and T1 mapping in a <5 minute FB non-ECG gated acquisition. Application of this technique pre and post contrast will enable a comprehensive assessment of cardiac function, Native T1, LGE and ECV in under 15-minutes. The specific aims of this proposal are (1) to develop a 2D CAT- SPARCS technique to simultaneously acquire cine, T1 maps and LGE images during a free-breathing cardiac self-gated acquisition, (2) to extend the 2D CAT-SPARCS to provide whole heart simultaneous acquisition of cine, T1 mapping and LGE images using simultaneous multi-slice (SMS) and 3D spiral acquisition techniques, and (3) to validate the CAT-SPARCS technique against the clinical gold standard breath-held ECG-gated clinical techniques in normal subjects and patients being evaluated for HF. Successful completion of this grant will result in the development and validation of a highly efficient technique for simultaneous T1 mapping and cine imaging which will demonstrate high accuracy and repeatability significantly shortening the CMR examination.