Idaho INBRE Bioinformatics Core

项目摘要/摘要生物信息学核心组成部分 爱达荷州INBRE-4生物信息学核心将整合网络基础设施工具和资源， 生物信息学/生物统计咨询和生物信息学培训。核心将在计算上支持- 在广泛的细胞信号科学主题下进行深入研究。设施物理上位于UI处， ISU和BSU，并向INBRE网络开放。在用户界面上，IBEST包括计算资源核心、 基因组学资源核心和光学成像核心。ISU的分子研究核心设施 包括DNA和RNA测序、先进成像和流式细胞术。在北卡罗来纳州立大学，生物分子 研究中心包括蛋白质组学和代谢组学、蛋白质-蛋白质分子相互作用和成像。 Ka Cornell是现任生物信息学核心主任(INBRE-3)，并将在INBRE-4期间继续担任这一角色。 他具有丰富的管理经验和一个已获得资助的积极研究项目，非常有资格 由NIH、NSF、USDA和国防部提供。由INBRE所有合作伙伴的代表组成的生物信息学委员会 各机构将指导核心使用和教育资源。成员拥有生物信息学方面的专业知识， 生物信息学教育，或核心设施运营经验。以前的进展是显著的，而且 亮点包括：(1)INBRE发起的核心现在由大学支持，(2)核心用户增加到1,700人， (3)将生物信息学纳入所有INBRE机构的科学课程(35门课程)，(4)理科/博士课程 在伊利诺伊大学攻读生物信息学和计算生物学，以及(V)在刘易斯大学攻读生物信息学学士/学士学位。 克拉克州立学院(阿贝)。这个新的学士/学士专业通过教师/学生的研究得到了INBRE的支持， 新教师招聘、新设备采购以及与研究密集型大学的网络合作。 让研究人员和学生熟悉生物信息学工具和资源的计划包括竞争 INBRE中具有科学价值的项目和讲习班/研讨会的技术准入补助金(TAG) 学生计划。生物信息学将继续纳入课程和研究。INBRE机构 将继续为本科生/研究生使用本地和远程生物信息学服务器 教育。核心将与西北知识网络合作，实现高带宽网络和 安全的数据存储。爱达荷州INBRE网站的专门部分，生物信息学教育 存储库，组织讲座、实验室练习、评估工具和补充材料 供教职员工和学生使用。生物信息学核心的一项创新是共享已建立的程序和 通过与蒙大拿州和新墨西哥州的INBRE网络三州区域联盟(RAIN)进行基础设施建设 INBRES。这种协作将减少冗余，增加跨学科核心使用和研究 教师之间的合作，并扩大学生的生物信息学研究和教育机会。 汇集的资源包括(I)爱达荷州的生物信息学学位课程，(Ii)爱达荷州的生物统计学和代谢组学 蒙大拿州INBRE，以及(Iii)新墨西哥州INBRE的前沿测序和生物信息学培训。

Project Summary/Abstract Bioinformatics Core Component The Idaho INBRE-4 Bioinformatics Core will integrate cyberinfrastructure tools and resources, bioinformatics/biostatistical consulting, and bioinformatics training. The Core will support computationally- intensive research under the broad Cell Signaling scientific theme. Facilities are physically located at the UI, ISU, and BSU and open to the INBRE Network. At the UI, IBEST includes a Computational Resources Core, a Genomics Resources Core, and an Optical Imaging Core. At ISU, the Molecular Research Core Facility includes DNA and RNA sequencing, advanced imaging, and flow cytometry. At BSU, the Biomolecular Research Center includes proteomics and metabolomics, protein-protein molecular interactions, and imaging. KA Cornell is the current Bioinformatics Core Director (INBRE-3) and will continue in this role during INBRE-4. He is well qualified with strong administrative experience and an active research program that has been funded by NIH, NSF, USDA, and DOD. A Bioinformatics Committee with representatives from all INBRE partner institutions will guide Core use and educational resources. Members have expertise in bioinformatics, bioinformatics education, or experience in Core facility operations. Previous progress was significant, and highlights include (i) INBRE-initiated Cores are now university sustained, (ii) increased Core users to >1,700, (iii) integrated bioinformatics in science curricula at all INBRE institutions (35 courses), (iv) MS/PhD programs in Bioinformatics and Computational Biology at the UI, and (v) a new BA/BS degree in Bioinformatics at Lewis- Clark State College (a PUI). This new BA/BS major was INBRE-supported through faculty/student research, new faculty hires, new equipment purchases, and Network collaborations with research-intensive universities. Plans to familiarize researchers and students with bioinformatics tools and resources include competitive Technology Access Grants (TAGs) for scientifically meritorious projects and workshops/seminars in the INBRE Student Program. Bioinformatics will continue to be integrated into curricula and research. INBRE institutions will continue to use local and remote bioinformatics servers for hands-on undergraduate/graduate student education. The Core will partner with the Northwest Knowledge Network for high bandwidth networking and secure data storage. A dedicated section of the Idaho INBRE website, the Bioinformatics Educational Repository, organizes lectures, laboratory exercises, assessment tools, and supplementary materials for faculty and student use. An innovation of the Bioinformatics Core is to share established programs and infrastructure through a tri-state Regional Alliance of INBRE Networks (RAIN) with Montana and New Mexico INBREs. This collaboration will reduce redundancy, increase interdisciplinary Core use and research collaborations among faculty, and broaden bioinformatics research and education opportunities for students. Pooled resources include (i) bioinformatics degree programs in Idaho, (ii) biostatistics and metabolomics in the Montana INBRE, and (iii) leading-edge sequencing and bioinformatics training by the New Mexico INBRE.