Laboratory Animal Shared Resource

实验动物共享资源（LASR）的使命是促进人道关怀和使用 实验室动物，以支持在罗斯韦尔公园进行的基础和转化研究。一流设施和 兽医计划都是由AAALAC国际认证，证明了人道的承诺， 负责任的动物研究和对优秀科学的奉献。LASR旨在提供最高 动物护理标准，由专业技术人员执行日常健康观察的所有方面， 兽医医疗护理、设施和设备维护以及手术和技术服务。LASR 为CCSG成员提供全方位的实验动物护理和使用服务，包括屏障设施 全自动的环境控制，用于研究动物模型的住房。LASR提供 兽医医疗、动物健康监测、诊断实验室设施、辐照服务， 研究技术服务和教师培训，支持200多个动物护理和使用研究所 委员会批准的动物使用方案和专业畜牧业， 在生物安全柜内更换笼舍以维持病原体期间的所有饲养操作- 在微隔离（MI）笼舍系统中饲养的动物的自由环境。主场地是一个四层~ 5万 净平方英尺（nsf）动物园，于1998年开放，位于医学研究综合大楼。一个 另外9，000个nsf可在邻近的癌细胞中心大楼使用。动物的数量会波动 在该设施中饲养了39，000至42，000只动物。在报告所述期间（2013-2017年），LASR服务于 共有129名Roswell用户，其中106名（82%）是CCSG成员。LASR支持科学家进行 体内研究。为了促进癌症中心内研究项目的成功，LASR积极 参与改进程序，这些程序通常成为实现目标的新方法或创新 动物实验的建议。LASR的具体目标是：1）提供罗斯威尔公园CCSG成员 获得最先进的设施、专门的畜牧业和兽医服务， 他们的实验室动物用于研究; 2）推动从基础和转化的体外过渡 利用体内癌症动物模型进行临床应用和实践的研究; 3）提供知识 和技术支持，以协助基础和临床研究人员在所有CCSG计划在实验期间 设计，执行项目和手稿和/或赠款写作。LASR的目标是支持 癌症中心的生物医学研究，同时保持人道护理和使用的最高标准 实验室的动物。LASR将继续保持AAALAC国际认证， 动物护理的黄金标准。

The mission of the Laboratory Animal Shared Resource (LASR) is to promote the humane care and use of laboratory animals in support of basic and translational research conducted at Roswell Park. The facilities and veterinary program are both accredited by AAALAC International demonstrating the commitment to humane and responsible animal research and dedication to good science. LASR is designed to offer the highest standards of animal care, with an expert technical staff performing all aspects of daily health observations, veterinary medical care, facility and equipment maintenance and surgical and technical services. The LASR offers CCSG members a full spectrum of laboratory animal care and use services including barrier facilities with fully automated environmental controls for the housing of research animal models. The LASR provides veterinary medical care, animal health surveillance, diagnostic laboratory facilities, irradiation services, research technical services and faculty training in support of more than 200 Institute Animal Care and Use Committee-approved animal use protocols and specialized animal husbandry with trained staff that performs all husbandry manipulations during cage changing inside Bio-Safety cabinets for maintenance of a pathogen- free environment of animals held in micro isolation (MI) caging systems. The main site is a four-story ~50,000 net square feet (nsf) vivarium, which opened in 1998, located in the Medical Research Complex building. An additional 9,000 nsf is available in the adjacent Cancer Cell Center building. The animal inventory fluctuates between 39,000 to 42,000 animals housed in the facility. In the reporting period (2013-2017), the LASR served a total of 129 Roswell users, of which 106 (82%) were CCSG members. LASR supports scientists that conduct in vivo studies. To further the success of the research programs within the cancer center, the LASR is actively involved in refinement of procedures that usually become new methods or innovations to accomplish the goals of proposed animal studies. The Specific Aims of the LASR are: 1) To provide Roswell Park CCSG members access to state-of-the-art facilities, specialized husbandry and veterinary services for the housing and care of their laboratory animals used in research; 2) To propel the transition from basic and translational in vitro research into clinical application and practice using in vivo animal models of cancer; 3) To provide intellectual and technical support to assist basic and clinical investigators in all CCSG programs during experimental design, execution of projects and manuscript and/or grant writing. The goal of the LASR is to support biomedical research at the cancer center while maintaining the highest standards for the humane care and use of the laboratory animals. LASR will continue to maintain the AAALAC International accreditation for assurance of gold standards of animal care.