MSC 衍生的细胞外囊泡的检测方法和试剂盒-猫眼课题宝

MSC 衍生的细胞外囊泡的检测方法和试剂盒

批准号：

10227192

负责人：

JOHN P NOLAN

金额：

$89.09万

依托单位：

CELLARCUS BIOSCIENCES INC

依托单位国家：

美国

项目类别：

财政年份：

2020

资助国家：

美国

项目状态：

已结题

起止时间：

2020-08-01 至 2023-07-31

来源：

https://reporter.nih.gov/project-details/10227192

关键词：

Address Adipose tissue Affect Alleles Antibodies Antibody Affinity Antibody Specificity Automation Biological Assay Biological Sciences Biotechnology Bone Marrow Cell Culture Techniques Cell Therapy Cells Client Clinical Clinical Trials Color Controlled Environment Data Development Disease Distant Dose Engineering Feedback Flow Cytometry Fluorescent Antibody Technique Heterogeneity Immunoassay International Laboratories Measurement Measures Membrane Proteins Monitor Monoclonal Antibodies Optics Organ Performance Pharmacologic Substance Phase Preparation Production Property Protocols documentation Reagent Regenerative Medicine Reporting Reproducibility Research Research Personnel Resolution Role Safety Sampling Services Societies Standardization Surface Technology Testing Therapeutic Therapeutic Agents Time Tissues Training Umbilical cord structure Vesicle Work analytical method biomarker panel design detection limit dosage extracellular vesicles in vitro activity in vivo interest liquid biopsy mesenchymal stromal cell novel therapeutics potential biomarker reagent standard regenerative regenerative cell regenerative therapy tool vesicular release

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中文摘要

翻译

摘要所有细胞都释放小的细胞外囊泡（EV），这些囊泡可以将货物运送到其他细胞，它们的功能。间充质基质细胞（MSC）释放具有再生活性的EV 其代表了潜在有价值的新治疗剂。实现这种潜力受到缺乏分析方法来表征MSC EV，其作用机制，并建立效力和剂量标准。我们将生产高解决方案分析工具的MSC电动汽车，将解决这些限制，并使他们的开发新的治疗实体。

英文摘要

Abstract All cells release small extracellular vesicles (EVs) that can carry cargo to other cells to affect their function. Mesenchymal stromal cells (MSCs) release EVs that have regenerative activities in vitro and in vivo and which represent potentially valuable new therapeutics. The realization of this potential is hindered by a lack of analytical methods to characterize MSC EVs, determine their mechanisms of action, and establish potency and dosage criteria. We will produce high resolution analysis tools for MSC EVs that will address these limitations and enable their development as new therapeutic entities.

期刊论文(1)

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会议论文

Rigor and reproducibility: status and challenges for single vesicle analysis.

DOI： 10.20517/evcna.2022.28

发表时间： 2022

期刊：

Extracellular vesicles and circulating nucleic acids

影响因子： --

作者：

[Nolan, John P., Chiu, Daniel T., Welsh, Joshua A.]