Undergraduate Research Experiences in Neurogenetics and Neurogenomics

拟议的计划是为10名本科生提供神经遗传学和神经基因组学下一代测序(NGS)分析的暑期研究经验。NGS改变了基因组学领域，并日益渗透到生物科学、研究和医学的方方面面。利用NGS来了解大脑和神经疾病是生物医学科学的主要前沿之一，并将在不久的将来和未来几十年推动该领域的进步。神经科学领域的研究人员将会非常需要具备与基因组学相关的强大数据分析技能。这种需求在生物科学研究生课程和生物医学专业学校对定量分析技能的日益重视中得到了明显的体现。为了满足这一需求，我们将建立一个名为“神经遗传学和神经基因组学中的布鲁斯基因组学(BIG-NGG)”的项目。它将利用由加州大学洛杉矶分校定量和计算生物科学研究所(QCB)和QCB合作实验室支持的现有夏季项目“基因组学中的棕熊”的基础设施。《大夏天》包括侧重于NGS数据分析技能的实用研讨会教程和在基因组学方面的实践研究经验。拟议的R25项目将允许另外10名学生参加BIG，特别是了解不断增长的神经遗传学和神经基因组学前沿研究领域。这些学生将是定量或生物科学专业的学生，进入他们的三年级和四年级。我们预计，我们的许多参与者将拥有这项研究经验，作为继续生物医学研究的起点，无论是定量生物科学博士项目，如生物信息学博士项目，还是神经科学博士项目。

The proposed program is to provide a summer research experience in next generation sequencing (NGS) analysis for neurogenetics and neurogenomics for 10 undergraduate students. NGS has transformed the field of genomics and is increasingly permeating all aspects of biosciences research and medicine. Using NGS to understand the brain and neurological disease is one of the major frontiers in biomedical science and will drive advances in the field in the near future and for decades to come. There will be a huge need for researchers in neuroscience with strong data analysis skills relevant to genomics. This need is evident in the increasing emphasis on quantitative analysis skills in biosciences graduate programs as well as in biomedical professional schools. To address this need, we will establish the program called “Bruins in Genomics in Neurogenetics and Neurogenomics (BIG­NGG)”. It will leverage the infrastructure of an existing summer program “Bruins in Genomics (BIG­Summer)”, supported by the Institute for Quantitative and Computational Biosciences (QCB) at UCLA, and the QCB Collaboratory. BIG­ Summer consists of a combination of practical workshop tutorials that focus on NGS data analysis skills, and a hands-on research experience in genomics. The proposed R25 program will allow 10 additional students to participate in BIG, and specifically to learn about the growing and cutting-edge research field of neurogenetics and neurogenomics. The students will be quantitative or biosciences majors entering their junior and senior years. We expect that many of our participants will have this research experience serve as a launching point for continuing in biomedical research in either quantitative biosciences Ph.D. programs such as a Bioinformatics Ph.D. program or a Neuroscience Ph.D. program.