Undergraduate Research Experience in Neuropsychiatric Genomics

神经精神基因组学本科研究经验

• 批准号: 9390070
• 负责人: ELEAZAR ESKIN
• 金额: $ 8.59万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-02-01 至 2020-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9390070
• 关键词: Address; Aptitude; Area; Big Data; Bioinformatics; Biological; Biological Sciences; Biology; Biomedical Research; Computational Biology; Computational Science; Country; Data; Data Analyses; Data Science; Data Set; Development; Diagnostic; Education; Education Projects; Educational Curriculum; Educational workshop; Exposure to; Faculty; Funding; Future; Genetic; Genome; Genomics; Grant; Health; Historically Black Colleges and Universities; Income; Individual; Institutes; Journals; Laboratories; Los Angeles; Medicine; Mentors; Minority; National Institute of Mental Health; Neurosciences; Publications; Quantitative Reasoning; Readiness; Research; Research Infrastructure; Research Personnel; Research Project Grants; Schools; Series; Speed; Students; System; Therapeutic; Time; Training; United States National Institutes of Health; Woman; Workforce Development; base; career; career development; clinical practice; collaboratory; education planning; education research; epigenome; experience; faculty mentor; genome sequencing; graduate school preparation; graduate student; innovation; medical schools; neurobehavioral; neuropsychiatric disorder; neuropsychiatry; next generation sequencing; programs; public health relevance; recruit; skills; statistics; student mentoring; student training; summer program; summer research; tool; transcriptome sequencing; undergraduate research; undergraduate student; whole genome

 DESCRIPTION (provided by applicant): This proposal is to develop a UCLA summer undergraduate research experience (R25) in Next Generation Sequencing (NGS) analysis. NGS has revolutionized the field of genomics and is increasingly permeating all aspects of biosciences research and medicine. This development has triggered a huge need for data analysis skills among researchers and professionals. As biosciences graduate programs and biomedical professional schools are rapidly adapting their curricula towards a greater emphasis on quantitative analysis skills, it has become apparent that the current pool of applicants who have an understanding and hands-on experience in quantitative analysis of `omic datasets remains exceedingly shallow. Indeed, without prior computational biosciences research experience it is difficult to evaluate applicants for their aptitude in quantitative analysis skill. In this post-genome era of biosciences research, a lack of aptitude in quantitative analysis skills will hamper graduate students and biomedical researchers through their careers. The proposed research education plan will address the need for an applicant pool with the hands-on experience in genomics analysis necessary to be successful in either graduate or professional schools. Specifically this new R25 program will leverage existing infrastructure that provides such an experience through workshops in NGS analysis: the "Bruins in Genomics" (BIG-SUMMER) program of the UCLA Quantitative and Computational Biology Institute (QCB). The new R25 program will enable UCLA to provide undergraduates, recruited nationally, with a specialized summer experience focused on neuropsychiatric genomics (BIG-NPG). BIG-NPG will combine the NGS workshops of the QCB with individual mentored research projects and journal clubs overseen by faculty in the UCLA Center for Neurobehavioral Genetics (CNG). These faculty are investigating the genetic and genomic basis of neuropsychiatric disorders through several collaborative NIMH grants. These projects will offer the undergraduate students the opportunity to conduct analyses on exceptional datasets covering a wide range of NGS applications (including whole genome sequencing, transcriptome sequencing, and epigenome sequencing). Participating in the program will enable students to gain a potentially career defining research experience in the genomics of neuropsychiatric disease.

 描述（由适用提供）：该建议是在下一代测序（NGS）分析中开发UCLA夏季本科研究经验（R25）。 NGS彻底改变了基因组学领域，并越来越渗透到生物科学研究和医学的各个方面。这一发展引发了研究人员和专业人员之间数据分析技能的巨大需求。随着Biosciences研究生课程和生物医学专业学校正在迅速调整其目前的流程，以更加重视定量分析技能，很明显，在对OMIC数据集进行定量分析方面具有理解和动手经验的当前应用程序仍然非常浅。确实，没有事先的计算生物科学研究经验，就很难评估其在定量分析技能方面的能力。在这个生物科学研究后的基因组时代，定量分析技能缺乏能力将使研究生和生物医学研究人员通过其职业发展。拟议的研究教育计划将满足申请人池的需求，并具有在研究生或专业学校中取得成功的基因组学分析经验的经验。具体而言，该新的R25计划将利用现有的基础架构，通过NGS分析中的研讨会提供这种经验：UCLA定量和计算生物学研究所（QCB）的“基因组学”（基因组学）（大夏）计划。新的R25计划将使UCLA能够为全国招募的本科生提供专门的夏季经验，以神经精神病学基因组学（Big-NPG）。 NPG将在UCLA神经行为遗传学中心（CNG）的教师（CNG）中监督的QCB的NGS研讨会与个人有指导的研究项目和期刊俱乐部相结合。这些教师正在研究神经精神疾病的遗传和基因组基础，这是通过几种协作的NIMH补助金。这些项目将为本科生提供对涵盖广泛NGS应用程序（包括整个基因组测序，转录组测序和表观基因组测序）进行特殊数据集进行分析的机会。参加该计划将使学生能够获得潜在的职业，以定义神经精神病的基因组学研究经验。