Child Health Research Center

项目摘要 此更新申请（RFA-HD-18-011）用于支持儿童健康研究中心 （CHRC）在华盛顿大学医学院。儿科医生-科学家发挥着至关重要的作用 在促进改善儿童健康的知识方面发挥作用。为了满足国家不断发展的需要， 补充儿科医生，科学家管道在初级教师水平，我们的计划支持一个 每年为3名学者提供2-3年的职业发展途径， 华盛顿大学医学院和医学中心的生物医学资源 校园正如我们过去22年所做的那样，我们中心的长期目标是发展 学者们将他们的研究工作集中在儿科疾病导向生物学上， 基础科学的进步，如发育生物学，细胞生物学，免疫学， 遗传学/基因组学和系统生物学。该提案的具体目标包括：1）保护 指导研究经验，与成熟的研究人员，包括广泛的 华盛顿大学医学院和儿科系内的学科，2） 实验室管理，科学严谨性，统计学， 和负责任的研究行为，3）个性化的具体课程的基础上，学者的 研究领域（例如，生物信息学，活细胞成像），4）持续反馈给学者， 导师和CHRC领导，以及5）促进女学者的发展， 代表性不足的少数民族。该计划，现在二十二岁，有一个恒星的跟踪记录， 超过国家基准（“K12到K 08/23”转换率为63%，“K到R”转换率出色 转换率为59%;全国平均水平<40%，分别），并将最终关闭 基础科学家和儿科临床医生之间的知识差距。加里A.西尔弗曼医学博士，博士将 担任项目主任，大卫亨斯塔德，医学博士。将担任培训主任。加拿大人权委员会和 它的学者将继续利用我们的机构资助的最先进的核心设施，提供， 例如，全基因组/外显子组DNA测序、生物信息学、冷冻EM成像、基因组编辑 和模型动物的发展，以促进儿科疾病状态的研究。远景目标 的CHRC正在实现其学者有助于我们对人类的理解 发展性疾病，同时演变成下一代的科学 领导者，榜样和导师为后代的儿科学者。

Project Summary Abstract This renewal application (RFA-HD-18-011) is for support of the Child Health Research Center (CHRC) at Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician-scientist pipeline at the junior faculty level, our program supports a mentored career development pathway for 3 Scholars per year for 2-3 years by leveraging a wealth of biomedical resources within the Washington University School of Medicine and the Medical Center campus. As we have done for the past 22 years, the long-term objective of our Center is to develop Scholars that focus their research efforts on Pediatric disease-oriented biology by applying recent advances in the basic sciences, such as developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators encompassing a wide range of disciplines within the Washington University School of Medicine and the Department of Pediatrics, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship and responsible conduct of research, 3) individualized specific coursework based on the Scholars’ areas of investigation (e.g., bioinformatics, live-cell imaging), 4) continuous feedback to the Scholars, mentors and CHRC leadership, and 5) foster the development of Scholars who are women and underrepresented minorities. The program, now twenty-two years old, has a stellar track record by exceeding national benchmarks (”K12 to K08/23” conversion rate of 63% and an outstanding “K to R conversion” rate of 59%; national average <40%, respectively), and will ultimately close the knowledge gap between basic scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D. will serve as Program Director, and David Hunstad, M.D. will serve as Training Director. The CHRC and its Scholars will continue to utilize our institutionally-funded state-of-art core facilities that provide, for example, whole genome/exome DNA sequencing, bioinformatics, cryo-EM imaging, genome editing and model animal development, to facilitate the study of Pediatric disease states. The long-term goals of the CHRC are being realized as its Scholars contribute to our understanding of human developmental diseases for decades to come, while evolving into the next generation of scientific leaders, role models and mentors for subsequent generations of Pediatric Scholars.