Improved Delivery System for Drug-Coated Balloon Therapy

项目摘要/摘要 我们建议开发一种新型的血管成形术球囊充气系统来提高药物包衣的疗效 球囊血管成形术。动脉粥样硬化，其特征是脂肪物质在内部沉积斑块 动脉壁，由于梗阻性狭窄可导致外周动脉疾病(PAD)的发展 为四肢提供血液的动脉。PAD经常引起各种各样的缺血症状 包括疼痛、无法愈合的动脉供血不足溃疡、下肢组织丢失和坏疽。经皮穿刺术 药物包衣球囊血管成形术对PAD的阻塞已观察到减轻症状，影响抢救 四肢并延长生存时间。

Project Summary/Abstract We propose to develop a novel angioplasty balloon inflation system to improve the efficacy of drug-coated balloon angioplasty. Atherosclerosis, characterized by the deposition of plaques of fatty material on the inner walls of arteries, can lead to the development of peripheral arterial disease (PAD) due to obstructive narrowing of arteries that supply blood to the extremities. PAD frequently causes a wide variety of ischemic symptoms including pain, non-healing arterial insufficiency ulcers, lower limb tissue loss and gangrene. Percutaneous drug-coated balloon angioplasty of PAD blockages has been observed to reduce symptoms, salvage affected limbs and prolong survival.